is a common sleep disorder that occurs when a person has difficulty falling asleep, staying asleep, or both. It can lead to daytime sleepiness and have a negative impact on daily functioning and well-being.
help people with insomnia by blocking the effects of orexin, a brain chemical that stimulates wakefulness.
are a type of neurotransmitter, chemical messengers in the body’s nervous system. They are produced in the hypothalamus region of the brain.
Orexins appear to affect
the entire central nervous system and seem to play an important role in a host of functions, including sleep, appetite, energy expenditure, mood, and cardiovascular and cognitive function.
It’s believed that one of the primary roles of orexins is to regulate the
sleep-wake cycle and that orexins stimulate the release of neurotransmitters that boost alertness, including
While other types of sleep medication cause sedation, DORAs treat insomnia by
the drive to stay awake
Research has shown that compared with other prescription sleep aids, DORAs may have fewer undesirable side effects, such as memory issues, behavior changes, and medication dependence.