When Less is more
BD™ Small Batch products leverage BD Horizon™ Dri technology which enables streamlined sample preparation while delivering increased consistency when compared to liquid reagents. Small Batch products are unit dosed pre-formulated products for: • Immune System Research • Selected Cell Therapy Research • Optimizing Tumor Microenvironment Research BD™ Small Batch products arrive ready-to-use in individual sample size. All multicolor tubes are cap free reducing ergonomic risk.
BD Horizon™ Dri technology
Cap free
Products
Overview
TBNK + CD20
Monoset
Memory T-Cell
Treg
Open +
BD Small Batch reagents are unit sized, pre-formulated and performance optimized multicolor panels (and other reagents including buffers) that leverage BD Horizon™ Dri technology for use in:
Immune monitoring research
powered by
BD Small Batch Workflow
* If cocktail contains >1 BD Horizon™ Brilliant Dye, add BD Horizon™ Brilliant Stain Buffer (BSB)
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Overview
TBNK + CD20
Overview
TBNK + CD20
Key features of the Small Batch reagents include:
streamlined sample preparation
Immuno-oncology research
Cell therapy research
Tumor microenvironment analysis
Customer Approved
Performance optimized on BD FACSLyric™ Research Flow Cytometer Supported with BD FACSuite™ Research Software analysis template
Optimized
Pre-formulated and ready-to-use in a dried format
Standardized
Modular design: Consensus backbone + open channels for drop-ins
Flexible
Informed by:
Innovative and Differentiated
streamlined sample preparation
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TTDR
Standard Experimental Workflow
BD Horizon Dri (Chroma) Experimental Workflow
Customer Voice Collaborations Consensus Guidelines High-Impact Publications BD Innovation
BD Horizon™ Dri (Chroma) BD Horizon™ Brilliant Dyes BD Trucount™ Tubes BD Quantibrite™ Beads Proprietary Enzyme Reagents
Unique Materials:
Enabled by cutting-edge BD technologies including BD Horizon Brilliant dyes, BD Horizon Dri Chroma technology, Trucount tubes, BD Quantibrite beads and proprietary enzymes.
TBNK+ CD20
Monoset
Memory T-Cell
TTDR
Treg
Products
Overview
Overview
TBNK + CD20
Monoset
Memory T-Cell
Treg
TTDR
powered by BD
®
®
BD Horizon™ Dri (Chroma) Experimental Workflow
®
®
BD Horizon Dri TBNK + CD20 Panel
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Optimized for Immune Monitoring Research
CD3 FITC-A
CD16+56 PE-A
CD8 APC-Cy7-A
CD3-
CD4+CD8-
CD16856-
CD16856+CC D19+
CD19+
CD16856-CD19
CD16856+ CD19-
CD4+CD8+
CD4-CD8-
CD4-CD8+
SSC-A
CD4 PE-Cy7-A
CD19 APC-A
CD45+
CD3+ CD4+
CD3+ CD8+
CD3-
CD3- CD19-
3
4
CD4+CD8-
CD4+CD8+
1
2
CD4-CD8+
CD4-CD8-
CD3-CD19+CD20+CD16-CD56-
CD3-CD19-CD16+CD56+
NK-cell
Determining percentages or counts of CD3+CD4+ lymphocytes can be useful in monitoring human immunodeficiency virus (HIV)–infected individuals Individuals with HIV typically exhibit a steady decrease of CD3+CD4+ lymphocyte counts as the infection progresses
T-cell
DATA
CD3-CD19-CD20-CD16+CD56+
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PRODUCT INFORMATION
B-cell
CD4+CD8-
CD4+CD8+
CD4-CD8+
CD4-CD8-
CD3-CD19+CD16-CD56-
CD3-CD19+CD20+CD16-CD56-
CD3-CD19-CD20-CD16+CD56+
CD3-CD19-CD16+CD56+
BD Horizon™ Dri TBNK + CD20 Panel Product Information
Part Number
Kit Contains
Price
625642
5 Tubes of BD Horizon™ Dri TBNK + CD20 Panel
PANEL composition
Format
Specificity
Clone
FITC PE PerCP-Cy™5.5 PE-Cy™7 APC APC-Cy™7 V450
CD3 CD16/56 CD45 CD4 CD19 CD8 CD20
SK7 B73.1/NCAM16.2 2D1 SK3 SJ25C1 SK1 L27
CD3-CD19+CD16-CD56-
T-Cell
CD3+CD4+ percentages or counts and total T and B lymphocytes are used to characterize and monitor some forms of immuno-deficiency and autoimmune diseases
B-cell
NK lymphocytes identified as CD3– and CD16+ and/or CD56+ have been shown to mediate cytotoxicity against certain tumors and virus infected cells
NK-cell
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PRODUCT INFORMATION
For research use only
Additional Resources
Overview
Monoset
Monoset
Overview
Test Size
1 test (Dried reagent cocktail) per tube
$220/kit
Figure 1 Flow cytometric analysis results
Liquid
Dry
Figure 2 Absolute count of lymphocytes
data
Start ordering
BD Horizon™ Dri TBNK + CD20 Multicolor Panel was designed for clinical research based on key feedback from Mass General Hospital and Harvard Medical School. The addition of CD20 to a standard TBNK analysis expands the utility of a very common test. Applications for this tube in research and clinical trials include monitoring immune responses to CD20 depletion therapies.
Characterizes T, B and NK cells
Efficient: Eliminates manual pipetting
Flexible: Open channels for liquid drop-ins
Product Features:
CD4 PE-Cy™7
CD8 APC-Cy™7
Standardized: All-in-one dried format reduces variability.
Provides absolute counts when paired with BD Trucount™ Tubes
Compensation Kit
Stained samples (using BD Multitest 6-color TBNK reagent with a CD20 V450 drop-in and BD Horizon Dri TBNK+CD20 tubes) prepared using three donors were transferred to BD Trucount™ tubes, acquired using the BD FACSLyric™ or BD FACSCanto™ systems and analyzed for determination of absolute counts of lymphocytes in blood (Figures 2A and 2B).
TBNK+ CD20
Monoset
Memory T-Cell
TTDR
Treg
Products
Overview
1 tube of:
CD3-CD19-CD20-CD16+ CD56+
CD3-CD19+CD16-CD56-
CD3-CD19+CD20+ CD16-CD56-
Compensation Kit
CD4 PE-Cy™7
CD8 APC-Cy™7
Immune Monitoring of Patients Receiving Rituximab Therapy
Immune Monitoring of Patients Receiving Rituximab Therapy
Technical Data Sheet (TDS) – BD Horizon™ Dri TBNK + CD20
Technical Data Sheet (TDS) – BD Horizon™ Dri TBNK + CD20
CD20 Depletion
CD20 Depletion
Overview
Products
TBNK + CD20
Monoset
Memory T-Cell
Treg
TTDR
Overview
TBNK + CD20
Monoset
Memory T-Cell
Treg
TTDR
* Cy is a trademark of General Electric Company
™
* Cy is a trademark of General Electric Company
HLA-DR+
CD16+
CD14+HLA-DR+CD16+
CD14+ HLADR+ CD16+ CCR2lo
CD16-
CD14+HLA-DR+CD16-
Classical Monocytes
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CD14+HLA-DR+CD16-
CD14+HLA-DR+CD16+
BD Horizon™ Dri Monoset Multicolor Panel was designed based on published consensus guidelines to identify and characterize classical, intermediate and non-classical subsets of monocytes in humans. These levels are quantitated by both absolute number and frequency of each subset. This quantitative value add is key because it enables standardization of your own data across multiple studies. Applications for this tube in research and clinical research trials include but are not limited to cardiology, sepsis, atherosclerosis and predictive biomarkers for immuno-oncology.
Optimized for Immunotherapy Research and Clinical RESEARCH Trials
Singlets
HLA-DR+
Non-Classical Monocytes
CD14+ HLADR+ CD16+ CCR2Hi
Intermediate Monocytes
CD14+
CD16+
CCR2lo
CCR2hi
CD14+HLA-DR+CD16-
1
2
CCR2lo
CCR2hi
BD Horizon Dri Monoset Panel
TBNK + CD20
Memory T-Cell
TBNK + CD20
Memory T-Cell
PRODUCT INFORMATION
DATA
For research use only
Additional Resources
BD Horizon™ Dri Monoset Panel Product Information
Part Number
626486
Kit Contains
Price
5 Tubes of BD Horizon™ Dri Monoset Panel
Test Size
1 test (Dried reagent cocktail) per tube
$175/kit
PANEL composition
Format
Specificity
Clone
FITC PE PerCP APC
CD16 HLA-DR CD14 CD192(CCR2)
3G8 L243 MP9 LS132.1D9
PRODUCT INFORMATION
data
Figure 2 Absolute count of lymphocytes
Absolute Counts
Positive cells (% of Lymphocytes)
Figure 1 Flow cytometric analysis results
Liquid
Dry
Start ordering
Characterizes classical, intermediate and non-classical monocytes
Standardized quantification (via ABC* units) when paired with BD Quantibrite™ Beads
Analysis template with gating strategy for BD FACSuite™ Research Software
Standardized: All-in-one dried format reduces variability.
Efficient: Eliminates manual pipetting
Flexible: Open channels for liquid drop-ins
Product Features:
CD14+
CD14+ HLA-DR+
HLA-DR+
CD14+
HLA-DR+
CD14+ HLA-DR+
More resources
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TBNK+ CD20
Monoset
Memory T-Cell
TTDR
Treg
Products
Overview
CD14+ HLA-DR+
CD14+HLA-DR+CD16-
Technical Data Sheet (TDS) – BD Horizon™ Dri Monoset
Technical Data Sheet (TDS) – BD Horizon™ Dri Monoset
BD FACSuite™ Research Software Analysis Template – BD Horizon™ Dri Monoset
BD FACSuite™ Research Software Analysis Template – BD Horizon™ Dri Monoset
Overview
Products
TBNK + CD20
Monoset
Memory T-Cell
Treg
TTDR
Overview
TBNK + CD20
Monoset
Memory T-Cell
Treg
TTDR
*Antibody Bound per Cell
™
Flexible: Open channels for liquid drop-ins
CD3+CD4+
CD3+CD8+
CD4+CD45RA+ CD197+CD95-
CD8 T-Cell
CD3+
Lymphs
CD45RA-
CD4+CD45RA-CD27+
CD14+
CD4+
CD8+CD45RA-CD27+
CD8+CD45RA+ CD197+CD95-
CD8+CD45RA-CD27-
CD8+CD45RA+ CD197+CD95+
CD8+CD45RA+ CD197-
CD4+CD45RA+ CD197-
CD4+CD45RA+ CD197+CD95+
CD4+
CD4 RA-
CD8+
CD4 T-Cell
CD45RA+
CD45RA+
CD45RA-
CD4+CD45RA-CD27-
Central memory t-cells
Effector memory T-cells
Naïve T-Cells
T-Memory Stem Cells
Effector T-Cells
Optimized for Cell Therapy Research and immune system research
BD Horizon™ Dri Memory T-Cell Tube is a 7-color panel that was performance-optimized for use in clinical research and cell therapy applications. The tube contains a dried, pre-aliquoted multicolor cocktail comprising markers that are well-established and widely used for the characterization of CD4 and CD8 naïve and memory T-cell subsets. The identification and characterization of these T-cell subsets are critical in a variety of clinical research applications, including immunity studies, vaccine research and various T-cell therapies.
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BD Horizon Dri
Monoset
Treg
Monoset
Treg
PRODUCT INFORMATION
DATA
More resources
For research use only
Additional Resources
BD Horizon™ Dri Memory T-Cell Panel Product Information
CD95 PE-Cy™7 CD3 APC-H7 CD27 APC-R700 CD45RA BV605
PANEL composition
Format
Specificity
Clone
FITC PE-Cy7 APC-R700 APC-H7 V450 V500C BV605
CD197 CD95 CD27 CD3 CD4 CD8 CD45RA
150503 DX2 M-T271 SK7 SK3 SK1 HI100
PRODUCT INFORMATION
data
Figure 2 Absolute count of lymphocytes
Absolute Counts
Positive cells (% of Lymphocytes)
Figure 1 Flow cytometric analysis results
Liquid
Dry
Products
Overview
TBNK+ CD20
Monoset
Memory T-Cell
TTDR
Treg
Overview
TBNK+ CD20
Monoset
Memory T-Cell
TTDR
Treg
Start ordering
Characterizes naïve, effector, central and stem cell memory T-cell subsets
Analysis template with gating strategy for BD FACSuite™ Research Software
Standardized: All-in-one dried format reduces variability.
Efficient: Eliminates manual pipetting
Flexible: Open channels for liquid drop-ins
Product Features:
Part Number
653848
Kit Contains
Price
5 Tubes of BD Horizon™ Dri Memory T-Cell Panel
One Compensation Kit
Test Size
1 test (Dried reagent cocktail) per tube
$375/kit
CD8+
CD4 RA+
4 Tcm
4 Teff-mem
4 Naive
4 Eff
4 Tscm
CD8 RA-
CD8 RA+
8 Naive
8 Eff
8 Tscm
4 Tscm
8 Tcm
TBNK+ CD20
Monoset
Memory T-Cell
TTDR
Treg
Products
Overview
Kit Contains
Compensation Kit
1 tube of:
MORE RESOURCES
Compensation Kit
Technical Data Sheet (TDS) – BD Horizon™ Dri Memory T-Cell
Technical Data Sheet (TDS) – BD Horizon™ Dri Memory T-Cell
BD FACSuite™ Research Software Analysis Template – BD Horizon™ Dri Memory T-Cell
BD FACSuite™ Research Software Analysis Template – BD Horizon™ Dri Memory T-Cell
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Overview
Products
TBNK + CD20
Monoset
Memory T-Cell
Treg
TTDR
Overview
TBNK + CD20
Monoset
Memory T-Cell
Treg
TTDR
™
Memory T-Cell Panel
* Cy is a trademark of General Electric Company
PANEL composition
Optimized for Cell Therapy Research and Immune System Research
BD Horizon™ Dri Treg Tube is a 7-color panel that was performance optimized for immune system research and cell therapy research. This panel contains a dried pre-aliquoted antibody cocktail comprising markers used for the characterization of FoxP3+ naïve, transitional and effector Treg subsets. Applications for this panel in research and clinical research trials include but not limited to auto-immunity studies, transplant studies, tumor microenvironment studies and infection.
BD Horizon Dri Treg Panel
Memory T-Cell
TTDR
Memory T-Cell
TTDR
PRODUCT INFORMATION
DATA
For research use only
Additional Resources
data
Figure 2 Absolute count of lymphocytes
Absolute Counts
Positive cells (% of Lymphocytes)
Figure 1 Flow cytometric analysis results
Products
Overview
TBNK+ CD20
Monoset
Memory T-Cell
TTDR
Treg
Overview
TBNK+ CD20
Monoset
Memory T-Cell
TTDR
Treg
Start ordering
Characterizes naïve, transitional and effector Treg subsets
Analysis template with gating strategy for BD FACSuite™ Research Software
Standardized: All-in-one dried format reduces variability.
Efficient: Eliminates manual pipetting
Flexible: Open channels for liquid drop-ins
Product Features:
BD Horizon™ Dri Treg Panel Product Information
CD4 PerCP-Cy™5.5 CD45RA PE-Cy™7 CD127 APC-R700 CD3 APC-H7
Part Number
626498
Kit Contains
Price
5 Tubes of BD Horizon™ Dri Treg Panel
One Compensation Kit
Test Size
1 test (Dried reagent cocktail) per tube
$400/kit
Tube 1
Format
Specificity
Clone
BB515 PerCP-Cy™ 5.5 PE-Cy™ 7 APC APC-R700 APC-H7
CD25 CD4 CD45RA CD161 CD127 CD3
2A3 SK3 L48 DX12 HIL-7R-M21 SK7
PRODUCT INFORMATION
Tube 2
Format
Specificity
Clone
PE
FoxP3
236A/E7
More resources
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CD25++
CD25++CD127-
FoxP3+
Naïve Treg Cells
HLA-DR+
2
Close X
Lymphs
CD4+
CD3+CD4+
CD4+
CD3+CD4+
CD25++CD127-FoxP3+CD161-CD45RA+
CD25++CD127-FoxP3+CD161-CD45RA-
CD25++CD127-FoxP3+CD161+CD45RA-
Transitional Treg Cells
Effector Treg Cells
CD25+CD127-
CD25++CD127-FoxP3+CD161-CD45RA+
CD25++CD127-FoxP3+CD161-CD45RA-
CD25++CD127-FoxP3+CD161+CD45RA-
TBNK+ CD20
Monoset
Memory T-Cell
TTDR
Treg
Products
Overview
PANEL composition
Kit Contains
5 Tubes of BD Horizon™ Dri Treg Panel
Compensation Kit
1 tube of:
CD3+CD4+
MORE RESOURCES
Technical Data Sheet (TDS) – BD Horizon™ Dri Treg
Technical Data Sheet (TDS) – BD Horizon™ Dri Treg
BD FACSuite™ Research Software Analysis Template – BD Horizon™ Dri Treg
BD FACSuite™ Research Software Analysis Template – BD Horizon™ Dri Treg
PANEL composition
Compensation Kit
TTDR
CD3+CD4+
Overview
Products
TBNK + CD20
Monoset
Memory T-Cell
Treg
TTDR
Overview
TBNK + CD20
Monoset
Memory T-Cell
Treg
TTDR
™
* Cy is a trademark of General Electric Company
Tube 2
Figure 1 Flow cytometric analysis results
Liquid
Optimized for Tumor Microenvironment Research
BD Horizon™ Dri Tumor & Tissue Dissociation Reagent (TTDR) was designed for gentle and effective dissociation of tumors and tissue for single-cell studies. BD TTDR is optimized to maximize cell yields, while minimizing cell death and epitope / antigen damage.
Mechanical
Tumor Tissue
Filtration
Medical dissociation
Centrifugation (TIL recovery)
Mechanical (non-enzymatic)
Enzymatic
Tumor Tissue
TTDR reaction (with gentle agitation)
Addition of reaction halting solution
Centrifugation (TIL recovery)
TTDR (enzymatic)
Workflow Comparison for Harvesting TIL’s
Immunotherapies targeting the tumor Microenvironment
Immunotherapies targeting the Tumor Microenvironment
Workflow Comparison for Harvesting TIL’s
A therapy targeting the tumor microenvironment
Immue checkpoint blockade
A therapy targeting the tumor microenvironment
T Cell therapy
A therapy targeting the tumor microenvironment
DC vaccine
A therapy targeting the tumor microenvironment
Peptide vaccine
cancer associated firbroblasts
CAF
endothelial cells
EC
myeloid-derived suppressor cells
MDSC
tumor associated macrophages
TAM
monocytes
Mono
natural killer cells
NK
dendritic cells
DC
regulatory T Cells
Treg
BD Horizon™Dri Tumor & Tissue Dissociation Reagent
Treg
Treg
Treg
TTDR
PRODUCT INFORMATION
DATA
For research use only
Additional Resources
BD Horizon™ Dri Tumor & Tissue Dissociation Reagent Product Information
Part Number
661563
Kit Contains
Price
15 Vials of BD Horizon™ Dri TTDR
Test Size
1 test (Dried reagent) per vial
$650/kit
composition
Format
Specificity
Clone
FITC PE PerCP APC
CD16 HLA-DR CD14 CD192(CCR2)
3G8 L243 MP9 LS132.1D9
PRODUCT INFORMATION
data
Mechanical
Tumor Tissue
Filtration
Medical dissociation
Centrifugation (TIL recovery)
Mechanical (non-enzymatic)
Enzymatic
Tumor Tissue
TTDR reaction (with gentle agitation)
Addition of reaction halting solution
Centrifugation (TIL recovery)
TTDR (enzymatic)
Immunotherapies targeting the tumor Microenvironment
Workflow for Single Cell Suspension
Immunotherapies Targeting the Tumor Microenvironment
A therapy targeting the tumor microenvironment
Immue checkpoint blockade
A therapy targeting the tumor microenvironment
T Cell therapy
A therapy targeting the tumor microenvironment
DC vaccine
A therapy targeting the tumor microenvironment
Peptide vaccine
cancer associated firbroblasts
CAF
endothelial cells
EC
myeloid-derived suppressor cells
MDSC
tumor associated macrophages
TAM
monocytes
Mono
natural killer cells
NK
dendritic cells
DC
regulatory T Cells
Treg
Figure 1. Cell yield and viability
13 breast cancer biopsies were processed in parallel via Method 2 (current popular market offering) and using the BD workflow. Procedure for Method 2 was followed per manufacturer's instructions. The BD workflow consisted of manual mechanical mincing of tumor followed by 30-minute incubation with BD Horizon™ Dri Tumor & Tissue Dissociation Reagent (BD-TTDR). Samples were filtered using a 70-micron filter and single cell suspensions were analyzed on an automated cell counter. Mean viability (A), total cell yield (B) and viable cells/mg of tumor processed (C). Viable cells/mg for each of the 13 biopsies processed are shown in D. Viability across the two methods was comparable; however, the total number of cells liberated was consistently and significantly higher using the BD workflow.
Figure 2. Epitope Preservation
Surface marker expression was assessed across the BD catalog in a mixed sample of two different cancer cell lines (RWPE-1 and MDA-MB-231) and PBMC from a donor pool (stimulated & unstimulated with PHA for 18 hrs). A total of 10 different populations were defined in this mixed sample: 1- RWPE, 2- MDA-MB-231, 3-unstimulated non-T cells (CD3-), 4-unstimulated T cells (CD3+), 5-unstimulated monocytes, 6-unstimulated granulocytes, 7-stimulated non-T cells (CD3-), 8-stimulated T cells (CD3+), 9-stimulated monocytes and 10-stimulated granulocytes. For each marker, a single population (T cells, non-T cells etc.) was chosen for the analysis. This target population is indicated by a number (1-10) that references these population assignment numbers (column heading is “Pop”). The mixed cell sample was then exposed to TTDR for 30 minutes or left untreated. Markers that demonstrated less than 20% expression are represented as grey boxes; 47 total markers. Untreated and treated (exposed to enzyme) samples were compared using Stain Index (SI), Median Fluorescence Intensity (MFI) of positive signal and the % of the population that was clearly positive for a given marker (% Pos). Dark green indicates a change of less than 15%, light green indicates a change of 15-30% and yellow indicates a change of 30% or more compared to the untreated control.
Figure 3. Flow cytometry sample data
Figure 4. Genomic analysis
Xenograft breast tumors were dissociated into single-cell suspensions using the BD Horizon™ Dri Tumor & Tissue Dissociation Reagent (BD-TTDR) following the protocol described above. Human tumor cells and mouse infiltrates were sorted based on species specificity as defined by expression of mouse CD45+ H-2kd. The purity of the sorted cell populations as measured by flow cytometry was >98%. Using the 2 sorted populations along with the unsorted to purify genomic DNA and further NGS sequencing using the Ion Torrent Cancer Hotspot panel v.2, a range of variants was detected with intermediate signal strength in the unsorted population, demonstrating that sorting of target cells prior to NGS analysis minimizes the noise due to contaminating cell populations.
Gentle: Maximizes cell yields during dissociation, while minimizing cell death and epitope / antigen damage
Effective: Efficiently dissociates a variety of tumor types to enable and empower single-cell studies
Accurate: Maintains the heterogeneity and diversity of your samples, ensuring precise results
Product Features:
Workflow for Single Cell Suspension and Downstream Analysis
Enzymatic Dissociation
Filtration, RBC Lysis and Wash
Cell Enumeration
FC Analysis/Sorting
Gene Expression Analysis
DNA Sequencing
Start ordering
Mechanical Dissociation
More resources
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TBNK+ CD20
Monoset
Memory T-Cell
TTDR
Treg
Products
Overview
MORE RESOURCES
AACR Poster 2015
AACR Poster 2016
Mol Cancer Res. 2017 Apr;15(4):429-438
Oncotarget 2019 Vol. 10; No.38: 3592-3604
Isolation of Tumor Infiltrating Lymphocytes (TILs) Using TTDR
AACR Poster 2015
AACR Poster 2016
Mol Cancer Res. 2017 Apr;15(4):429-438
Oncotarget 2019 Vol. 10; No.38: 3592-3604
Isolation of Tumor Infiltrating Lymphocytes (TILs) Using TTDR
Overview
Products
TBNK + CD20
Monoset
Memory T-Cell
Treg
TTDR
Overview
TBNK + CD20
Monoset
Memory T-Cell
Treg
TTDR
BD Horizon Dri
Tumor & Tissue Dissociation Reagent
™
Cancer associated fibroblasts
T-cell therapy
CAF
Endothelial cells
EC
Natural killer cells
NK
Regulatory T-cells
Treg
Monocytes
Mono
Dendritic cells
DC
Tumor associated macrophages
TAM
Myeloid-derived suppressor cells
MDSC
A therapy targeting the tumor microenvironment
Peptide vaccine
A therapy targeting the tumor microenvironment
DC vaccine
A therapy targeting the tumor microenvironment
Immune checkpoint blockade
