Disrupting and Curing
Neurological Diseases
in Our Lifetimes
Neurological Diseases
in Our Lifetimes
Cleveland Clinic is transforming the landscape of neurological care.
One in every six people in the world has a neurological disease
One in six people worldwide suffers from a neurological disease. As lifespans increase, the risk of devastating neurodegenerative illnesses like Alzheimer’s, Parkinson’s, and ALS grows exponentially.
Cleveland Clinic is on a mission to answer a fundamental question: why do some brains stay healthy while others fall ill? Solving this mystery is key to preventing, treating, and curing neurological diseases.
Your partnership with Cleveland Clinic has never been more vital.
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We invite you to join us, and together we'll make history.
Your investment makes
innovation possible
To advance research and precision medicine, neurological care must be digitized. This new building enables the collection and
use of patient data to drive discoveries and improve care.
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Digitization
Partner with the leader in neurological breakthroughs
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The world looks to us to disrupt and cure neurological diseases — today. We invite you to join us, and together we'll make history.
Your investment
makes innovation possible
9500 Euclid Avenue, Cleveland, Ohio 44195 | 800.223.2273 | © 2025 Cleveland Clinic. All Rights Reserved.
cost to build
$1 billion
square feet
1 million
inpatient rooms
210
operating rooms
16
ICU beds
45
exam rooms
120
MRI areas
6
Our planned Neurological Institute
The waiting room experience shifts from passive to purposeful. Instead of simply waiting, patients engage in digital assessments that capture neurological data—such as cognitive function, mobility, and dexterity.
Real-time insights help physicians personalize care before the appointment begins. Integrating technology enhances efficiency, improves patient engagement, and ensures every moment in the care journey is meaningful.
A Smarter, More Engaging Waiting Room
Together, we can build a center for breakthrough therapies, innovative care, and hope
Robert Bermel, MD
Kristen Vargo, DNP, RN, NE-BC
Director of Nursing
Every aspect of the building's design prioritizes patient experience. A standout feature is the integration of virtual technology in all inpatient rooms, enabling continuous, 24/7 monitoring of patients.
SEEG
We launched the first U.S. program for epilepsy patients using the minimally invasive SEEG procedure.
Our mobile stroke unit delivers clot-busting therapy with exceptional speed, including treating a patient in just 8 minutes.
We developed online tools patients can use to test for neurological issues anytime, anywhere.
#1
We were first to use laser ablation surgery to attack “inoperable” brain cancers.
Our world-first use of deep brain stimulation for stroke patients has restored functionality beyond expectations.
Distance Health
André Machado, MD, PhD
The building connects physicians, providers, and technology, serving as a multiplier to expand neurological care—improving quality and accessibility for more people, including local communities.
Natural light is a key feature in the new building, improving patient recovery and caregiver well-being. Every unit—ambulatory, inpatient, and operating rooms—maximizes sunlight to enhance mood and help neurological patients stay oriented.
Thoughtfully placed windows ensure both patients and caregivers benefit from outdoor visibility, a major upgrade from previous spaces
Lighting for
Healing and Well-Being
Discovery
Shazam Hussain, MD
The innovative hub unites research and care, where clinicians and scientists collaborate to rapidly transform discoveries into breakthrough therapies for patients.
Cutting-edge technology enhances patient care, from virtual monitoring in inpatient rooms to digital assessments in waiting areas.
Physicians access real-time neurological data for faster diagnoses and precise treatments, ensuring patients benefit from the latest advancements.
Technology Transforming Care
M. Shazam Hussain, MD
Vice Chief, Safety, Quality & Patient Experience
The innovative hub unites research and care, where clinicians and scientists collaborate to rapidly transform discoveries into breakthrough therapies for patients.
André Machado, MD, PhD
Chief, Neurological Institute
The building connects physicians, providers, and technology, serving as a multiplier to expand neurological care—improving quality and accessibility for more people, including local communities.
Robert Bermel, MD
Director, Mellen Center for Multiple Sclerosis
To advance research and precision medicine, neurological care must be digitized. This new building enables the collection and use of patient data to drive discoveries and improve care.
Outdoor Terrace
Our mobile stroke unit delivers clot-busting therapy with exceptional speed, including treating a patient in just 8 minutes.
SEEG
We launched the first U.S. program for epilepsy patients using the minimally invasive SEEG procedure.
We developed online tools patients can use to test for neurological issues anytime, anywhere.
#1
We were first to use laser ablation surgery to attack “inoperable” brain cancers.
Our world-first use of deep brain stimulation for stroke patients has restored functionality beyond expectations.
Let’s act now.
The world looks to us to disrupt and cure neurological diseases — today. We invite you to join us,
and together we'll make history.
The Neurological Institute that
Hope is Building
We are not just building a building. We are offering hope to patients and their families dealing with the consequences of neurological disease. Hope for discoveries, for treatments, for cures.
Our New Neurological Institute By the Numbers
Today, neurological services are offered in several locations on our main campus, some housed in aging facilities that are part of the original buildings of Cleveland Clinic, founded more than 100 years ago. To meet the increasing demand for care, to recruit and train top talent and to support technological advances in the field, we will create the world’s smartest building — the first neurological care center purpose-built for the digitization of neurological data and distance health. We will bring the best minds in neuroscience together under one roof to spur collaboration and creativity and to centralize care for patients for maximum convenience.
“What we want to cause is a creative friction between these experts,” says Andre Machado, MD, PhD, Chair of Cleveland Clinic’s Neurological Institute. “Because it is this friction that sparks the new interesting ideas.” One of them? Coming up with a procedure to treat brain disease that is as routine as placing a stent in a blocked artery. Spanning 1 million square feet, this building of hope and inspiration will be filled with light and connections to nature, its every detail intended to be functional, long-lasting and spiritually uplifting.
The design is a collaboration between celebrated architects and institute leaders who have an intimate understanding of the unique needs of their patients.
“Imagine walking the campus of the Cleveland Clinic as an able-bodied person — it’s a workout,” says Dr. Machado. “Now imagine doing it wheelchair-bound or on a walker. It’s not what Cleveland Clinic is about. Our new building will allow the unified care that puts the patient at the center of everything — exactly where they should be.”
Inside the World’s
Smartest Building
Patients flipping through outdated magazines in cramped cubbies are but a distant memory in our Waiting Room of the Future.
This revolutionary space will measure a patient’s movement — her gait and walking speed — through technology-enabled data capture from the moment she arrives. Each footprint will provide information about her condition to her care team. Using an iPad, she will complete a series of cognitive and motor tests to assess her neurological function. When she arrives at her doctor’s office, her exam will be mostly done, leaving her more time to discuss test results and create an individualized treatment plan with her physician.
cost to build
$1 billion
square feet
1 million
inpatient rooms
210
operating rooms
18
intensive care
unit beds
45
exam rooms
120
stories
13
The Waiting Room of the Future
The debilitating symptoms of many neurological diseases make access to healthcare especially difficult. For example, the risk of seizures can limit the ability of people with epilepsy to travel safely to outpatient clinic appointments.
We have removed those barriers by harnessing distance health technologies such as virtual visits and at-home patient management tools pioneered at the Neurological Institute. These include a smartphone app that replicates a few key aspects of a physical neurological exam; a short online test that goes beyond standard dementia screening; and wearable devices like smart watches to detect signs of cognitive impairment.
Telemedicine Unbound
Cold, impersonal exam rooms have no place in our leading-edge home for neurological care. Patients and their loved ones will enter a warm, welcoming physician’s study with wide doorways and flexible seating designed to accommodate wheelchairs or stretchers and multiple family members. Patients won’t sit on the hard surface of an exam table but on a couch where they can speak to their doctors eye to eye.
Large screens embedded into walls will allow physicians to display patient data and imaging to help patients better understand their conditions and treatment options and “beam” family members, translators and subspecialists into office visits using videoconferencing technology.
Patient-focused Exam Rooms
At Cleveland Clinic, we aim to provide the most advanced care for today’s patients while investigating new therapies to improve treatment for the patients of tomorrow. As we pursue this mission, we must keep our patients safe and provide a healing environment for body, mind and spirit.
Open spaces filled with natural light will allow ease of movement for those using walkers or wheelchairs. Hallways will be more than just paths; they’ll double as rehabilitation areas. Rails throughout the building will assist patients during physical therapy and extend into patient rooms and bathrooms. Our goal is to become the first “no-falls” hospital in the country.
Safety First
Home
Take a tour of our new neurological institute.
Get in Touch
Make a Gift
The world is looking to us to change the course of human health by disrupting and curing neurological diseases. Today. In our own lifetimes.
Dream big with us
9500 Euclid Avenue, Cleveland, Ohio 44195 | 800.223.2273 | © 2023 Cleveland Clinic. All Rights Reserved.
We invite you to join us, and
together we'll make history.
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At Cleveland Clinic, we are creating the Neurological Institute of the future that the world so desperately needs.
We established the first program in the U.S. for epilepsy patients using a minimally invasive procedure known as SEEG — stereoelectro-encephalography — to pinpoint the precise location of seizure sites deep in the brain.
Our mobile stroke unit allows for some of the most efficient delivery times for clot-busting drug therapy, including recent treatment of a patient in just eight minutes.
We developed online tools patients can use to test for neurological issues anytime, anywhere.
We were first to use laser ablation surgery to attack “inoperable” brain cancers.
Our first-in-the-world application of deep brain stimulation therapy to stroke patients has restored functionality to a degree no one thought possible.
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#1
SEEG
Our mobile stroke unit delivers clot-busting therapy with exceptional speed, including treating a patient in just 8 minutes.
SEEG
We launched the first U.S. program for epilepsy patients using the minimally invasive SEEG procedure.
We developed online tools patients can use to test for neurological issues anytime, anywhere.
#1
We were first to use laser ablation surgery to attack “inoperable” brain cancers.
Our world-first use of deep brain stimulation for stroke patients has restored functionality beyond expectations.
