Common Questions: SGLT2 Inhibitors
What drugs are SGLT2 inhibitors?
Can SGLT2 inhibitors help you lose weight?
What are the side effects of SGLT2 inhibitors?
Can you take SGLT2 inhibitors with metformin?
Can SGLT2 inhibitors help lower blood pressure?
Common Questions: Colon and Rectal (Colorectal) Cancer
What are the early warning signs of colorectal cancer?
How long does it take for colorectal cancer to develop?
Are colon cancer, rectal cancer, and colorectal cancer all the same?
Can you die from colorectal cancer?
Where is the first place colorectal cancer spreads?
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The seven brand-name drugs Invokana, Farxiga, Jardiance, Glyxambi, Synjardy, Steglatro, and Xigduo XR are all considered SGLT2 inhibitors. These drugs may help improve insulin resistance and obesity, but for now, they’re approved only for people with type 2 diabetes.
Blood in the stool, a change in bowel habits marked by constipation or diarrhea, fatigue, weakness, abdominal pain, bloating, and weight loss are among the early signs of colon cancer.
These drugs are primarily prescribed for managing type 2 diabetes and helping prevent complications like heart disease and kidney failure, but research shows they may help you lose weight, too. That’s great news for diabetes management, as weight loss helps your body use insulin more effectively.
Most cases of colorectal cancer begin as a polyp, and it may take as long as 10 to 15 years to become cancerous. For this reason, regular screening to identify and remove polyps is the best way to prevent colon cancer.
These drugs can pose both minor and major side effects. While everyone responds to SGLT2 inhibitors differently, common side effects include urinating more frequently, becoming dehydrated, and developing urinary tract infections. Examples of more serious side effects are amputations, diabetic ketoacidosis, and injury to the kidneys.
Colon cancer begins in the colon and rectal cancer begins in the rectum, but both areas are part of the digestive system. Because of this, cancers that occur in either area are sometimes referred to as colorectal cancer.
Yes. In fact, drugs like Jardiance and Farxiga aren’t first-line treatments for blood sugar control. Instead, doctors commonly prescribe them as add-on drugs with metformin to help people with type 2 diabetes better manage their health.
Yes. The odds of survival are highest for colorectal cancers caught at an early stage. For example, localized colorectal cancer that has not spread outside the colon or rectum has a 90 percent five-year survival rate, while those cancers that have spread to nearby or distant organs have 75 percent and 14 percent five-year survival rates, respectively.
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Indeed they can, and that’s great news if you have diabetes, because the disease puts you at a higher risk of hypertension and heart disease. A 2015 meta-analysis found that, compared with placebo, the drugs helped lower both systolic and diastolic blood pressure. The first, top number indicates the max pressure your heart releases while beating, while the second, which appears on the bottom of your blood pressure reading, indicates your pulse pressure.
Colon cancer typically spreads to the liver first, though it can spread to other areas of the body, including the lungs and brain.
