1. Are JAK inhibitors more effective than biologics for treating ankylosing spondylitis?
3. Can I stay on top of recommended vaccines while taking a JAK inhibitor?
4. JAK inhibitors are so new — how do we know they’re safe?
5. Should I be worried about the black box warning on all JAK inhibitors?
2. Can JAK inhibitors be taken with other ankylosing spondylitis medications?
FAQs About JAK Inhibitors for Ankylosing Spondylitis
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6. Will I be able to afford this medication?
7. Do I need to take this medication forever?
Biologics and JAK inhibitors have demonstrated (using a clinical measuring tool) about the same efficacy rate, says Dubreuil. Efficacy is defined as a 40% improvement in at least three out of four main areas of treatment impact, without any worsening in the remaining area, she says.
Due to the risks of drug interactions or side effects, a JAK inhibitor is typically prescribed on its own, not in combination with other treatments like NSAIDs or biologics.
JAK inhibitors can increase your risk of infection, which makes vaccinations especially important. “I recommend everyone gets their vaccines before we start treatment,” Bose emphasizes.
Even though JAK inhibitors are a new treatment for ankylosing spondylitis, they’ve been used since 2012 to treat RA, another type of inflammatory arthritis. “All drugs have risks and side effects,” says Bose. But not treating or undertreating your disease also poses risks.
4. JAK inhibitors are so new — How do we know they’re safe?
While the black box warning may be concerning, “The FDA was pretty conservative and wanted to ensure that people are cautious,” explains Dubreuil, emphasizing that researchers are continuing to explore the effects of JAK inhibitors. “In a couple years’ time, we’ll have more information — and possibly a differently worded warning.”
While these drugs are very expensive, as long as you’re eligible to try a JAK inhibitor, most health insurance companies help foot the bill so you’re only responsible for your prescription plan’s copay. If your insurance plan doesn’t cover the cost of JAK inhibitors or you’re having trouble coming up with your copay, each drug manufacturer also offers patient assistance programs to help you save money on your medication.
“Ankylosing spondylitis is a chronic condition,” emphasizes Bose. “It’s hard to say how long you’re going to need medication. Some people require medication for a long time, and some don’t. Some want to taper off, and some would rather not because they’re scared of a relapse.” At the end of the day, it’s important to work with your doctor to discuss your individual circumstances and develop a plan that works best for you.
