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each gene type to learn more
EGFR
ALK
ROS1
BRAF
NTRK
EGFR
ALK
ROS1
BRAF
NTRK
BRAF
EGFR
Epidermal growth factor receptor (EGFR) is a protein that helps cells grow and divide. Mutated EGFR proteins send a signal that causes cells to grow out of control. EGFR inhibitors block this signal.
Drugs that target EGFR mutations:
• Afatinib
• Dacomitinib
• Erlotinib
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• Gefitinib
• Necitumumab
• Osimertinib
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Some NSCLC cells have a rearrangement in the anaplastic lymphoma kinase (ALK) gene, which produces an abnormal protein that causes the cells to grow and spread. Drugs that target this protein can help shrink lung cancer tumors.
Drugs that target ALK mutations:
• Alectinib
• Brigatinib
• Ceritinib
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• Crizotinib
• Lorlatinib
ALK
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Similar to the ALK mutation, a rearrangement in the ROS1 gene produces an abnormal protein that sends signals for cancer cells to grow and spread. ROS1 inhibitors block these signals.
Drugs that target ROS1 mutations:
• Ceritinib
• Crizotinib
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• Entrectinib
• Lorlatinib
ROS1
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A mutation in the BRAF gene makes a protein that helps drive cancer growth. Some drugs target this and related proteins.
Drugs that target BRAF mutations:
• Dabrafenib and trametinib, which are typically
given together
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BRAF
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Changes in NTRK genes can lead to abnormal cell growth and cancer. Targeted therapies target and disable proteins made by these genes.
Drugs that target NTRK mutations:
• Entrectinib
• Larotrectinib
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NTRK
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