How Biologics Work
Atopic dermatitis is partly caused by an overactive immune system, which triggers the release of inflammatory molecules called cytokines — particularly interleukin-4 (IL-4) — when it detects certain irritants, such as pollen or perfume.
This cascade of inflammation can cause the upper layer of skin, called the skin barrier, to produce less moisture than normal. This results in dry, cracked skin that’s prone to itching and irritation.
This process causes an overgrowth of bacteria and yeast to develop on the skin, leading to even more inflammation and a further reduction in moisture — a vicious cycle.
Current biologics work by binding to a receptor on the
IL-4 molecules, which prevents them from triggering the cascade of inflammation that causes itchiness and irritation. Halting this process then restores your skin to its normal state.