Delivery Method
IV infusion
Dosage
100 mg or 300 mg every 3 months
Most Common Side Effects
Stuffy nose and scratchy throat; hypersensitivity reactions (e.g., flushing)
Costs*/
Savings Program Availability
Eligible commercially insured patients can pay $0 per dose — includes up to $200 in administration
out-of-pocket fees per treatment. Coverage under Medicare and Medicaid varies. Lundbeck may offer assistance for
qualifying uninsured/
underinsured patients.
Efficacy in
Clinical Trials
Reduced monthly migraine days by about 4 for EM**;
51–54 percent reduction in migraine one day after infusion. Reduced monthly migraine days by about 8 for CM***;
52 percent reduction in migraine one day after infusion.
Minimum Eligible Age
18 years old
Eptinezumab (Vyepti)
Erenumab (Aimovig)
Fremanezumab (Ajovy)
Galcanezumab (Emgality)
Injection
Eligible commercially insured patients can pay $5 per month.
Coverage under Medicare and
Medicaid varies.
Amgen may offer assistance for qualifying uninsured/
underinsured patients.
Injection site reactions, constipation
70 mg or 140 mg
once monthly
Reduced monthly migraine days by about 3 for EM**.
Reduced monthly migraine days
by 7 for CM***.
18 years old
Injection
Eligible commercially insured patients can pay as little as $35 per dose. Medicare and Medicaid varies.
Lilly may offer assistance for qualifying uninsured/
underinsured patients.
Injection site reactions
240 mg (first dose) then 120 mg
once monthly
Reduced monthly migraine days by about 4 for both EM** and CM***. Reduction of about 69 hours of severe pain per month for EM** and about 103 fewer hours of severe pain per month for CM***
18 years old
Injection
Eligible commercially insured patients can pay as little as $15 per dose. Medicare and Medicaid varies.
Teva may offer assistance for qualifying uninsured/
underinsured patients.
Injection site reactions,
allergic reactions
225 mg once monthly (or 675 mg every
3 months)
Reduced monthly migraine days by 5.1 (monthly Ajovy use) and 5.2 (quarterly Ajovy use) days for EM**. Reduced monthly migraine days by 8.1 (monthly Ajovy use) and 7.2 (quarterly Ajovy use) days for CM***. Another study also showed improved symptoms of major depressive disorder in people with migraine.
6 years old
$10 month + $99 initial consultation fee (or copay)
No video visit required; will work with your chosen pharmacy/insurance benefits for certain meds, or can have meds directly shipped to your door; generics start at $15/mo out of pocket; also offers nonprescription migraine supplements
Unlimited 24/7 in-app messaging w/provider; treatment plan;
in-app access to migraine tracker; lifestyle coaching and CBT program for additional $50 (or covered by select insurance plans)
Not available
Cost
Rimegepant (Nurtec)
* Costs vary widely across states and depending on insurance plans.
** EM = Episodic Migraine
*** CM = Chronic Migraine
Eligible commercially insured patients can pay $0 per infusion every 3 months.
Coverage under Medicare and Medicaid varies.
Lundbeck may offer assistance for
qualifying uninsured/
underinsured patients.
Eptinezumab (Vypepti)
Efficacy in
Clinical Trials
Minimum
Eligible Age
6 years old
18 years old
* Costs vary widely across states and depending on insurance plans.
** EM= Episodic Migraine
*** CM= Chronic Migraine
Delivery Method
IV infusion
Dosage
100 mg to 300 mg every 3 months
Most Common Side Effects
Swelling of the nasal passages and back of throat; hypersensitivity reactions (i.e., flushing)
Savings Program Availability
Eligible commercially insured patients can pay $0 per infusion every 3 months.
Coverage under Medicare and
Medicaid varies.
Lundbeck may offer assistance for qualifying uninsured/
underinsured patients.
Efficacy in
Clinical Trials
Reduced monthly migraine days by about 4 for EM*;
51-54% reduction in migraine one day after infusion.
Reduced monthly migraine days by about 8 for CM**;
52% reduction day after infusion.
Minimum Eligible Age
18 years old
$10 month + $99 initial consultation fee (or copay)
No video visit required; will work with your chosen pharmacy/insurance benefits for certain meds, or can have meds directly shipped to your door; generics start at $15/mo out of pocket; also offers nonprescription migraine supplements
Unlimited 24/7 in-app messaging w/provider; treatment plan;
in-app access to migraine tracker; lifestyle coaching and CBT program for additional $50 (or covered by select insurance plans)
Not available
Cost
Rimegepant (Nurtec)
18 years old
Eligible commercially insured patients can pay $0 per infusion every 3 months.
Coverage under Medicare and Medicaid varies.
Lundbeck may offer assistance for
qualifying uninsured/
underinsured patients.
LEARN MORE
*Pricing varies widely across states and depending on insurance plans.
*EM= Episodic Migraine
**CM= Chronic Migraine
Delivery Method
Eptinezumab (Vyepti)
Erenumab (Aimovig)
Fremanezumab (Ajovy)
Galcanezumab (Emgality)
IV infusion
Costs*/
Savings Program Availability
Eligible commercially insured patients can pay $0 per dose — includes up to $200 in administration
out-of-pocket fees per treatment. Coverage under Medicare and Medicaid varies. Lundbeck may offer assistance for
qualifying uninsured/
underinsured patients.
Most Common Side Effects
Stuffy nose and scratchy throat; hypersensitivity reactions (e.g., flushing)
Dosage
100 mg or 300 mg every 3 months
Efficacy in
Clinical Trials
Reduced monthly migraine days by about 4 for EM**;
51–54 percent reduction in migraine one day after infusion. Reduced monthly migraine days by about 8 for CM***;
52 percent reduction in migraine one day after infusion.
Minimum Eligible Age
18 years old
Injection
Eligible commercially insured patients can pay $5 per month.
Coverage under Medicare and
Medicaid varies.
Amgen may offer assistance for qualifying uninsured/
underinsured patients.
Injection site reactions, constipation
70 mg or 140 mg
once monthly
Reduced monthly migraine days by about 3 for EM**.
Reduced monthly migraine days
by 7 for CM***.
18 years old
Injection
Eligible commercially insured patients can pay as little as $15 per dose. Medicare and Medicaid varies.
Teva may offer assistance for qualifying uninsured/
underinsured patients.
Injection site reactions,
allergic reactions
225 mg once monthly (or 675 mg every
3 months)
Reduced monthly migraine days by 5.1 (monthly Ajovy use) and 5.2 (quarterly Ajovy use) days for EM**. Reduced monthly migraine days by 8.1 (monthly Ajovy use) and 7.2 (quarterly Ajovy use) days for CM***. Another study also showed improved symptoms of major depressive disorder in people with migraine.
6 years old
Injection
Eligible commercially insured patients can pay as little as $35 per dose. Medicare and Medicaid varies.
Lilly may offer assistance for qualifying uninsured/
underinsured patients.
Injection site reactions
240 mg (first dose) then 120 mg
once monthly
Reduced monthly migraine days by about 4 for both EM** and CM***. Reduction of about 69 hours of severe pain per month for EM** and about 103 fewer hours of severe pain per month for CM***
18 years old
* Costs vary widely across states and depending on insurance plans.
** EM = Episodic Migraine
*** CM = Chronic Migraine