Target/Placement
Trigeminal nerve (forehead)
Approved for
Acute and preventive for migraine
Rx
No
Cost*
Notes
Cefaly
External trigeminal neurostimulation (eTNS)
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sugar, stevia
$389-$424, plus $25-$33 for
3 electrodes, ordered every 2-3 months
Possibly also helpful for light and sound sensitivity, nausea, and vomiting
gammaCore
Noninvasive vagus nerve stimulation (nVNS)
HeadaTerm 2
Transcutaneous electrical
nerve stimulation (TENS)
*Most U.S. insurers don’t include neuromodulation devices in their coverage plans; some device manufacturers offer patient assistant programs.
Vagus nerve (neck)
Yes
Acute and preventive for migraine and cluster headache; preventive for paroxysmal hemicrania and hemicrania continua
$200 a month for
unlimited use
Possibly also helpful
for nausea, vomiting, dizziness, vestibular
migraine symptoms
Trigeminal nerve (forehead)
No
Preventive for migraine
$130, plus $25 for 3 electrodes to last about one month, depending on use
A more budget-friendly version of Cefaly with
fewer frills
Target/Placement
Nerivio
Remote electrical neuromodulation (REN)
Relivion
Combined occipital
nerve-trigeminal nerve stimulation (ON-TNS)
SAVI Dual
Single-pulse transcranial magnetic stimulation (sTMS)
Nociceptive receptors; induces conditioned pain modulation (upper arm)
Cost*
Rx
Yes
Approved for
Acute and preventive for migraine
Notes
$49 for first device
(18 treatments),
$89 for refill devices
Recently approved for pediatric use ages 8+
Trigeminal nerves, occipital nerves (around the head)
Yes
Acute only for migraine
Initial fee of $150 for 60 days; can purchase for $650 thereafter; electrodes start
at $15 for box of 10
Other possible uses are being studied for depression, insomnia, ADHD.
Outer layers of brain
(back of head)
Yes
About $395 a month for unlimited treatments
The only neuromodulation device that uses magnetic pulses; no need for skin contact or electrodes.
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*Most U.S. insurers don’t include neuromodulation devices in their coverage plans; some device manufacturers offer patient assistant programs.
Acute and preventive for migraine
Target/Placement
Nerivio
Remote electrical neuromodulation (REN)
Relivion
Combined occipital
nerve-trigeminal nerve stimulation (ON-TNS)
SAVI Dual
Single-pulse transcranial magnetic stimulation (sTMS)
Nociceptive receptors; induces conditioned pain modulation (upper arm)
Cost*
Rx
Yes
Approved for
Acute and preventive for migraine
Acute and preventive for migraine
Notes
$49 for first device
(18 treatments),
$89 for refill devices
Recently approved for pediatric use ages 8+
Trigeminal nerves, occipital nerves (around the head)
Yes
Acute only for migraine
Initial fee of $150 for 60 days; can purchase for $650 thereafter; electrodes start
at $15 for box of 10
Other possible uses are being studied for depression, insomnia, ADHD.
Outer layers of brain
(back of head)
Yes
About $395 a month for unlimited treatments
The only neuromodulation device that uses magnetic pulses; no need for skin contact or electrodes.
LEARN MORE
*Most U.S. insurers don’t include neuromodulation devices in their coverage plans; some device manufacturers offer patient assistant programs.