Day 1: Infusion Day
The first visit is often the longest, as the team needs to see how your body reacts to the infusion, says Sohn. Keep the day open, line up a loved one for support and transportation, and plan for a quiet day at home afterward.
Weeks 2–4: The Loading Phase
To get the desired amount of medication, or therapeutic dose, in your system, you’ll return for a second “loading” dose, usually two to four weeks after the first infusion. This phase ensures the medication stays at a consistent level to fight inflammation effectively.
Weeks 4–12: Monitoring for Results
Some people notice improvements right away, such as less morning stiffness. Others may see reduced joint pain or swelling within the first four to six weeks. If you haven’t felt any changes after the 12-week mark, your doctor may suggest adjusting the dose or switching to a different drug class, says Sohn.
Months 6+: Long-Term Management
While side effects usually subside after six months, some fatigue may persist. On average, people on a GLP-1 or dual GIP/GLP-1 agonist see a 10 to 15 percent weight reduction over a year, but strength training and nutrition are vital to maintaining those results, says Velayati. You may need to take a GLP-1 or dual GIP/GLP-1 agonist over the long term to keep the weight off permanently, because stopping the medication may cause the weight to return.
Weeks 4–12: Monitoring for Results
Some people notice improvements right away, such as less morning stiffness. Others may see reduced joint pain or swelling within the first four to six weeks. If you haven’t felt any changes after the 12-week mark, your doctor may suggest adjusting the dose or switching to a different drug class, says Sohn.
Weeks 12+: Maintenance
Once the medicine is working, your schedule becomes more predictable. Depending on the drug, infusions may be once a month or every six to eight weeks. You’ll see your rheumatologist every four to six weeks initially to track your progress and ensure you’re heading in the right direction, says Sohn.
Ongoing: Progress Tracking
Keeping a diary or using an app to track morning stiffness, fatigue, and daily activities can help your doctor determine how well the IV biologic is working for you.
