FIRST
SECOND
THIRD
VEGFR TKIāBased Initial Therapy
ICI-Based Initial Therapy
FIRST
SECOND
THIRD
Sunitinib
Pazopanib
Cabozantinib
Cabozantinib
Nivolumab
Axitinib
Lenvatinib/Everolimus
Everolimus
Cabozantinib/Nivolumab
Lenvatinib/Pembrolizumab
Nivolumab
Axitinib/Pembrolizumab
Lenvatinib/Everolimus
Everolimus
Tivozanib
Ipilimumab/
Nivolumab
Cabozantinib
Lenvatinib/
Everolimus
Everolimus
Tivozanib
Axitinib/
Pembrolizumab
Axitinib/
Avelumab
Cabozantinib
Lenvatinib/
Everolimus
Everolimus
Tivozanib
Cabozantinib/
Nivolumab
Lenvatinib/
Everolimus
Everolimus
Tivozanib
Lenvatinib/
Pembrolizumab
Cabozantinib
Everolimus
Tivozanib
![](https://media-s3-us-east-1.ceros.com/harborside/images/2023/06/09/e4c5680bb2e435ce6b84435be1a8224d/processed-svg-image.svg)