Cirrhosis is the most severe stage of fibrosis. It develops when severe and widespread scarring replaces healthy
liver tissue. It may not be possible to reverse this scarring.
Decompensated cirrhosis is advanced cirrhosis that stops your liver from working as it should. It may lead
to life threatening liver failure that requires a liver
transplant to treat.
Fibrosis is a type of scarring that may develop from inflammation and damage in your liver. An estimated 10% to 25% of people with MASH develop fibrosis and later, cirrhosis.
Fibrosis ranges from mild to severe. Weight loss, lifestyle changes, and sometimes medication may help reverse fibrosis or stop it from getting worse.
Simple steatosis
Hepatocellular carcinoma (HCC) is a type of liver cancer that affects people with cirrhosis. It starts in liver cells but may spread to other body parts. Depending on the cause and stage of cirrhosis, as well as a person’s age and sex, the chances of developing liver cancer at 5 years after diagnosis is about 5% to 30%.
HCC may require a combination of surgery, radiation therapy, or medication to treat. Early diagnosis may help improve your treatment options and survival.
“Steatosis” is the medical term for fat buildup in your liver. Simple steatosis involves fat buildup with little to no inflammation or liver damage.
Metabolic dysfunction-associated liver (MASL), formerly known as nonalcoholic fatty liver (NAFL), is a type of simple steatosis that’s common in people with overweight or obesity. Weight loss and lifestyle changes may fully reverse MASL.
Steatohepatitis
Fibrosis
Cirrhosis
Liver Cancer
Other health conditions
certain types of cancer that start outside your liver
cardiovascular disease
type 2 diabetes
Nonalcoholic Fatty Liver Disease
Progression Guide
Steatohepatitis involves fat buildup and further inflammation in your liver. The inflammation may damage your liver and cause scarring.
Nonalcoholic steatohepatitis (NASH) or metabolic dysfunction-associated steatohepatitis (MASH) is more common than usual in people with overweight or obesity. Weight loss and lifestyle changes may help reverse MASH or stop it from worsening.
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MASLD also raises your risk of other health conditions, including:
Maintaining a moderate weight and practicing healthy lifestyle changes may reduce your risk of these complications.