A Smarter Solution
After
The Mission
This Harvard-developed breakthrough brings
long-lasting relief to eczema sufferers of all ages
Scroll to explore
As the cold season sets in and flare-ups become more common, it’s also a time when many look for new hope – and new solutions. Whether your eczema is chronic, seasonal, or something you’ve battled since childhood, Soteri Skin’s formula helps restore your skin’s natural environment, keeping your skin calm, pH balanced, itch and flare-free – for every age, from babies to adults.
The itching stopped and for the first time in years, my dry, flaky skin felt smooth again. I finally could enjoy life again, Soteri Skin gave me my confidence back
It all started with Dr. Rafel Pielak, a Harvard-trained biomedical Ph.D. who saw firsthand the toll eczema took on his wife. “She was constantly itchy and in pain,” he recalled. After dozens of failed treatments that brought only temporary relief, Dr. Pielak dove into the research, looking for a better way to treat eczema.
“From the beginning, we wanted to take a different path: to translate cutting-edge skin science into a topical, over-the-counter solution that anyone could use safely, without a prescription,” explains Dr. Pielak.
Soteri Skin’s breakthrough formula is the only topical that normalizes skin pH to an optimal 4.7 and maintains it for up to 12 hours, helping rebalance the microbiome, calm flare-ups, and activate enzymes essential for ceramide production and skin renewal. The result is all-day comfort from a light, non-greasy hydrating cream that delivers lasting relief. “Soteri Skin has given me my life back. No more itching, no more pain,” says Lacy.
Before
Board-certified dermatologist for 21 years and Soteri Skin medical advisor Dr. Peter Lio has dedicated his career to delivering real relief for those living with eczema. Seeing so many patients suffer from inflammatory skin conditions pushed him to focus on finding better ways to relieve eczema. He was drawn to Soteri Skin because it offered something truly different — the only formula designed to actually restore and maintain the skin’s pH balance. “For many patients, this is a transformative product,” Dr. Lio says.
How did you hear about UPNEEQ?
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Why did you decide to use it?
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Has it made a difference for you, and how so?
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Would you recommend to others, and why?
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What is UPNEEQ?
IMPORTANT SAFETY INFORMATION
UPNEEQ® (oxymetazoline hydrochloride ophthalmic solution), 0.1% is a prescription eyedrop used to treat low-lying lids (acquired blepharoptosis) in adults.
What warnings and precautions are associated with UPNEEQ?
EXPAND
Low-lying lids may be related to conditions such as stroke and/or brain aneurysm, Horner syndrome, myasthenia gravis, loss of the ability to move eye muscles, eye infection and eye tumors. Tell your doctor if you have any of these conditions.
UPNEEQ is a type of medication that may affect your blood pressure. If you have heart disease, uncontrolled high or low blood pressure, or feel faint at rest or when quickly standing up, you should call your doctor if your symptoms get worse.
For those battling eczema, finding a lasting solution can be a long and disheartening journey. “I tried steroids, medications, and top-brand eczema creams, but nothing helped,” said Lacy, who suffered from eczema on her hands for four years. Then she found Soteri Skin. Clinically tested and backed by rigorous research and breakthrough pH science, Soteri Skin takes a novel approach to eczema care, delivering long-lasting non-steroidal relief by correcting and maintaining your skin’s natural pH balance at the optimal level.
Developing a product specifically designed to target this root cause, which is pH imbalance, became the foundation of Soteri Skin. “In essence, the formulation mimics what healthy skin does naturally, helping it regain its pH and microbiome balance and resilience over time.” The results were remarkable. Within a month, his wife experienced clear, balanced skin for the first time in years. “Seeing her transformation convinced me to start Soteri Skin in order to develop products that can help millions of other eczema sufferers,” says Dr. Pielak.
How did you hear about UPNEEQ?
"
For those battling eczema, finding a lasting solution can be a long and disheartening journey. “I tried steroids, medications, and top-brand eczema creams, but nothing helped,” said Lacy, who suffered from eczema on her hands for four years. Then she found Soteri Skin. Clinically tested and backed by rigorous research and breakthrough pH science, Soteri Skin takes a novel approach to eczema care, delivering long-lasting non-steroidal relief by correcting and maintaining your skin’s natural pH balance at the optimal level.
UPNEEQ® (oxymetazoline hydrochloride ophthalmic solution), 0.1% is a prescription eyedrop
Not an actual patient.
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Harvard-Backed Innovation
As the new year approaches, there’s no better time to take control of stubborn eczema symptoms once and for all. While there is no cure for eczema, there is control. Discover the Soteri difference and experience real, lasting relief—clinically proven to work even for the most skeptical sufferers. In clinical trials, 100% of participants experienced significant improvement in overall skin health and 60% experienced complete eczema symptom relief. Start today with the Soteri Starter Kit, or bring comfort to little ones with Soteri’s Baby Eczema Relief Cream, safe for ages 0-5 years. Don’t wait to feel the difference — calm, balanced, itch-free skin is finally within reach.
New Year New You
For Soteri Skin, breakthrough eczema treatments are just the beginning. “Ultimately, we’re not just formulating creams, we’re building a scientific framework for maintaining and restoring the skin’s natural ecosystem,” says Dr. Pielak.
Soteri’s broader mission is perhaps best embodied by Co-Founder and CMO, Lama Mansour. From a young age, Mansour suffered from eczema so severely that she avoided wearing certain clothes to keep her rash-covered legs hidden. “I understand that eczema can have a real impact on people’s freedom and happiness" she says.
For Mansour, joining Soteri Skin was about so much more than business, it was about helping people live more comfortable and confident lives. “Success means helping millions of people in the United States and around the world live with joy and presence,” says Mansour.
What means the most to Soteri Co-Founder Mansour are the real human success stories, especially those shared by moms.“I’ve worked with many mothers who, for years, have been looking for solutions for their kids and babies, trying all the big name products, and nothing has worked,” she says. “Then they tried Soteri skin and they’re blown away by the results.”
Mom-Approved
There’s nothing more rewarding than bringing relief to your child. For moms everywhere, discovering Soteri Skin has been a game changer. “It’s a night-and-day difference,” says Allison Bast, mom to baby Jameson. “He used to wake up screaming, and now his back is totally clear. I have to attribute that to using Soteri Skin religiously.”
Success means helping millions of people in the United States and around the world live with joy and presence
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SPONSORED BY
By Josie Brocato on December 1, 2025
SHOP RELIEF
SHOP RELIEF
Slide To Reveal
An actual patient before and after Soteri Skin’s formula administration.
Most eczema creams only treat the surface, providing temporary moisture or relying on steroids to suppress symptoms. But eczema runs deeper than dry skin. “My goal was to recreate the function of the natural acid mantle—to restore its gentle buffering capacity, maintain the optimal pH environment, and support both the barrier and microbiome without causing irritation,” says Dr. Pielak. And because the formula is completely non-steroidal, it delivers results without the side effects commonly associated with steroid creams.
When the skin’s pH rises above its natural acidic range, as it normally does with eczema prone skin, it weakens the skin barrier and disrupts the microbiome, triggering irritation and flare-ups. What Dr. Pielak discovered was that lasting relief isn’t about adding more moisture, it’s about correcting and restoring pH balance.
Slide To Reveal
An actual patient before and after Soteri Skin’s formula administration.
SHOP RELIEF
SHOP RELIEF
SHOP RELIEF
Slide To Reveal
Soteri’s “ first patient” and Dr. Rafal’s wife, Samantha, before and after Soteri Skin’s formula administration.
Scroll to explore
As the cold season sets in and flare-ups become more common, it’s also a time when many look for new hope – and new solutions. Whether your eczema is chronic, seasonal, or something you’ve battled since childhood, Soteri Skin’s formula helps restore your skin’s natural environment, keeping your skin calm, pH balanced, itch and flare-free – for every age, from babies to adults.
It all started with Dr. Rafel Pielak, a Harvard-trained biomedical Ph.D. who saw firsthand the toll eczema took on his wife. “She was constantly itchy and in pain,” he recalled. After dozens of failed treatments that brought only temporary relief, Dr. Pielak dove into the research, looking for a better way to treat eczema.
“From the beginning, we wanted to take a different path: to translate cutting-edge skin science into a topical, over-the-counter solution that anyone could use safely, without a prescription,” explains Dr. Pielak.
Most eczema creams only treat the surface, providing temporary moisture or relying on steroids to suppress symptoms. But eczema runs deeper than dry skin. “My goal was to recreate the function of the natural acid mantle—to restore its gentle buffering capacity, maintain the optimal pH environment, and support both the barrier and microbiome without causing irritation,” says Dr. Pielak. And because the formula is completely non-steroidal, it delivers results without the side effects commonly associated with steroid creams.
When the skin’s pH rises above its natural acidic range, as it normally does with eczema prone skin, it weakens the skin barrier and disrupts the microbiome, triggering irritation and flare-ups. What Dr. Pielak discovered was that lasting relief isn’t about adding more moisture, it’s about correcting and restoring pH balance.
Developing a product specifically designed to target this root cause, which is pH imbalance, became the foundation of Soteri Skin. “In essence, the formulation mimics what healthy skin does naturally, helping it regain its pH and microbiome balance and resilience over time.” The results were remarkable. Within a month, his wife experienced clear, balanced skin for the first time in years. “Seeing her transformation convinced me to start Soteri Skin in order to develop products that can help millions of other eczema sufferers,” says Dr. Pielak.
Soteri Skin’s breakthrough formula is the only topical that normalizes skin pH to an optimal 4.7 and maintains it for up to 12 hours, helping rebalance the microbiome, calm flare-ups, and activate enzymes essential for ceramide production and skin renewal. The result is all-day comfort from a light, non-greasy hydrating cream that delivers lasting relief. “Soteri Skin has given me my life back. No more itching, no more pain,” says Lacy.
Harvard-Backed Innovation
Board-certified dermatologist for 21 years and Soteri Skin medical advisor Dr. Peter Lio has dedicated his career to delivering real relief for those living with eczema. Seeing so many patients suffer from inflammatory skin conditions pushed him to focus on finding better ways to relieve eczema. He was drawn to Soteri Skin because it offered something truly different — the only formula designed to actually restore and maintain the skin’s pH balance. “For many patients, this is a transformative product,” Dr. Lio says.
For Soteri Skin, breakthrough eczema treatments are just the beginning. “Ultimately, we’re not just formulating creams, we’re building a scientific framework for maintaining and restoring the skin’s natural ecosystem,” says Dr. Pielak.
A Smarter Solution
Soteri’s broader mission is perhaps best embodied by Co-Founder and CMO, Lama Mansour. From a young age, Mansour suffered from eczema so severely that she avoided wearing certain clothes to keep her rash-covered legs hidden. “I understand that eczema can have a real impact on people’s freedom and happiness" she says.
Success means helping millions of people in the United States and around the world live with joy and presence
"
"
For Mansour, joining Soteri Skin was about so much more than business, it was about helping people live more comfortable and confident lives. “Success means helping millions of people in the United States and around the world live with joy and presence,” says Mansour.
There’s nothing more rewarding than bringing relief to your child. For moms everywhere, discovering Soteri Skin has been a game changer. “It’s a night-and-day difference,” says Allison Bast, mom to baby Jameson. “He used to wake up screaming, and now his back is totally clear. I have to attribute that to using Soteri Skin religiously.”
The Mission
There’s nothing more rewarding than bringing relief to your child. For moms everywhere, discovering Soteri Skin has been a game changer. “It’s a night-and-day difference,” says Allison Bast, mom to baby Jameson. “He used to wake up screaming, and now his back is totally clear. I have to attribute that to using Soteri Skin religiously.”
As the new year approaches, there’s no better time to take control of stubborn eczema symptoms once and for all. While there is no cure for eczema, there is control. Discover the Soteri difference and experience real, lasting relief—clinically proven to work even for the most skeptical sufferers. In clinical trials, 100% of participants experienced significant improvement in overall skin health and 60% experienced complete eczema symptom relief. Start today with the Soteri Starter Kit, or bring comfort to little ones with Soteri’s Baby Eczema Relief Cream, safe for ages 0-5 years. Don’t wait to feel the difference — calm, balanced, itch-free skin is finally within reach.
Mom-Approved