LED or LASER
ILLUMINATION
CONFOCAL
SPINNING DISK
CUSTOM OPTICS
6 objective turret
Water immersion objectives
SCIENTIFIC
CMOS SENSOR
MAGNIFICATION CHANGER
AgileOptix™ technology offers a combination of a powerful solid-state light engine, custom optics, scientific CMOS sensor, and the ability to change between different disk geometries.
Cell painting image at 60X magnification captured under high-intensity laser illumination
LED light source
Gentle illumination compatible with up to 7 fluorescent channels:
DAPI, CFP, FITC, YFP, TRITC, TxRED, Cy5
Ideal for widefield, confocal and standard screening assays
7-Laser high-intensity light source
Powerful excitation compatible with up to 8 fluorescent channels
Including near infra-red illumination for wider spectral separation and more fluorophore options
DAPI, CFP, FITC, YFP, TRITC, TxRED, Cy5, Cy7
Boost acquisition speeds with significantly reduced exposure times, ideal for 3D and highly multiplexed assays
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Organoid image acquired with 50µm pinhole deep tissue disk
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Organoid image acquired with 60µm pinhole confocal disk
Multiple confocal disk geometries, including pinhole and slit configurations for high-throughput applications.
Standard disk (single): 60μm pinhole disk - great for wide range of 2D and 3D applications
Screening disk (dual): 60μm pinhole paired with 50μm slit disk - optimized for fast screening speeds
Deep tissue disk (dual): 50μm pinhole disks with smaller pinholes and spacing optimized for higher signal or deep sectioning in 3D structures
Proprietary AgileOptix™ Spinning Disk Technology
Live-cell time-lapse images acquired using water immersion objectives at 10X
Equipped with up to six objectives at any one time, with magnifications from 2X to 60X, including high NA and ELWD objectives, reducing the need for configuration changes. The system can also be equipped with up to 2 water immersion objectives. These offer signal increases of up to 4X, helping scientists see deeper into 3D and thick tissue samples with lower exposure times.
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6-Position automated objective changer with optional water immersion
PC-12 cells captured at 40X magnification
The ImageXpress HCS.ai system can be equipped with a magnification changer that can switch between 1X and 1.5X. This allows up to 12 magnifications in a single configuration without the need to switch objectives.
Automated magnification changer
HCT116 spheroid (cleared) imaged with 20x Water Immersion
A >5 mega pixel sCMOS sensor with large sensor size (224mm2) and a >3 log dynamic range with 16bit detector offers 95% peak quantum efficiency – enabling you to get clearer images faster.
sCMOS Sensor with exceptional sensitivity and wide field of view
