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Quiz Configuration
Which of the following best reflects this patient's Sjögren's disease activity?
Primarily sicca
Primarily functional, with sicca and intermittent quality-of-life impact
Multisystemic disease with sicca and significant quality-of-life impact
Multisystemic disease with sicca and significant quality-of-life impact
“Agreed. Multisystemic disease with sicca and significant quality-of-life impact is the most accurate classification. Carla’s symptoms go beyond dryness, including synovitis, persistent vasculitis, and fatigue that affect her daily life.”
Eric Anderson, MD, RhMSUS
Eric Anderson, MD, RhMSUS
“Her presentation is more consistent with multisystemic disease than primarily sicca. While dryness is present, Carla also has cutaneous vasculitis, joint inflammation, and pain.”
Primarily sicca
Eric Anderson, MD, RhMSUS
“Her disease activity is better described as multisystemic rather than functional. Carla’s persistent synovitis, vasculitis, and lifestyle disruption point to active systemic involvement.”
Primarily functional, with sicca and intermittent quality-of-life impact
Question 1 of 3
What do Carla's persistent joint symptoms, despite treatment with methotrexate, suggest?
No change needed—continue monitoring
Her symptoms are likely unrelated to SjD
Her disease may be refractory to current treatment and require escalation or reassessment
Her disease may be refractory to current treatment and require escalation or reassessment
“I agree. Her disease may be refractory to current treatment and require escalation or reassessment. Ongoing synovitis, despite immunosuppressive therapy like methotrexate, suggests inadequate disease control and the need to reevaluate her management plan.”
Eric Anderson, MD, RhMSUS
Question 2 of 3
Eric Anderson, MD, RhMSUS
“While some patients may require time to respond, Carla’s continued synovitis, despite being on methotrexate, suggests that her current treatment plan may not be working effectively.”
No change needed—continue monitoring
Eric Anderson, MD, RhMSUS
“Her symptoms align more with uncontrolled Sjögren’s disease than with an unrelated condition. With her confirmed diagnosis and ongoing inflammation, Carla’s joint symptoms are most likely a sign of active systemic disease.”
Her symptoms are likely unrelated to SjD
Next Question >
Do you think Carla is ready for a biologic therapy?
Yes
No
Yes
“Yes, I would consider Carla ready for a biologic therapy. Despite prior methotrexate treatment and a persistent need for corticosteroids, Carla continues to have sicca symptoms along with skin, joint, constitutional, and biological involvement. This degree of continuous multisystemic activity makes a strong case for moving to a biologic."
Eric Anderson, MD, RhMSUS
Question 3 of 3
Eric Anderson, MD, RhMSUS
“In my opinion, this is the right time to consider escalation to a biologic. Given Carla’s continued joint symptoms and return of purpura, despite immunosuppressive therapy, I’d be concerned her disease isn’t fully controlled.”
No
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