Patient Case #4 v5

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Quiz Configuration

Which of the following best reflects this patient's Sjögren's disease activity?

Primarily sicca

Primarily functional, with sicca and intermittent quality-of-life impact

Systemic disease with sicca and significant quality-of-life impact

“I agree. Systemic disease with sicca and significant quality-of-life impact is the most accurate classification. June’s dryness symptoms, severe fatigue, and lymph node involvement point to systemic disease that’s clearly affecting her daily life in a meaningful way.”

Eric Anderson, MD, RhMSUS

“This looks more like systemic disease than primarily sicca. June’s dryness symptoms are just one part of a broader symptom profile that also includes lymph node involvement, which points to systemic activity.”

Primarily sicca

Eric Anderson, MD, RhMSUS

“In my opinion, this is more consistent with systemic disease than just functional involvement. While there’s functional impact, systemic features like lymphadenopathy point toward a broader pattern.”

Primarily functional, with sicca and intermittent quality-of-life impact

Question 1 of 3

Do you think a treatment change is necessary?

Her symptoms are not that serious and don’t require a change

Her symptoms suggest suboptimal disease control and warrant reevaluation

Question 2 of 3

Eric Anderson, MD, RhMSUS

“Her symptoms suggest suboptimal disease control and warrant reevaluation. Given the persistence of systemic symptoms like swollen lymph nodes and severe fatigue, I’d be concerned that June’s disease activity isn’t fully controlled and needs a closer look.”

Her symptoms are not that serious and don’t require a change

Eric Anderson, MD, RhMSUS

“I agree. Her symptoms suggest suboptimal disease control and warrant reevaluation. Ongoing systemic symptoms, including severe fatigue and swollen lymph nodes, despite treatment, suggest the current approach may not be adequately controlling the disease.”

Her symptoms suggest suboptimal disease control and warrant reevaluation

Next Question >

Do you think June is ready for a biologic therapy?

Yes

“Yes, I believe June is ready for a biologic. June's severe fatigue and continuing sicca, despite symptomatic management, indicate inadequate disease control. The emergence of lymphadenopathy further suggests disease progression. Given these developments, escalation to biologic therapy should be considered.”

Eric Anderson, MD, RhMSUS

Question 3 of 3

Eric Anderson, MD, RhMSUS

“I don't agree. June's continuing symptoms and new-onset lymphadenopathy suggest that her disease is progressing. Given that lymphadenopathy is a potential predictor of lymphoma development, I believe she now meets the criteria for biologic therapy.”

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