Structure
Structure
Structure
The linker is a molecular structural component that connects the targeting ligand to the chelator. The linker maintains the stability and integrity throughout the process, allowing it to bind effectively to cancer cells.3
Chelator
Radioisotope
Linker
Targeting ligand
Structure
Cancer cell
The chelator is a chemical agent that securely binds to the radioisotope, ensuring its stable attachment and proper delivery to the target cancer cells. The chelator plays an important role in preventing the radioisotope from dissociating, which could lead to unintended radiation exposure.3,6
The targeting ligand is the molecule that identifies and binds to specific markers on cancer cells and is designed to selectively deliver therapeutic radiation to tumor cells or cells of the tumor microenvironment with potentially limited damage to healthy cells.1,3,4
The radioisotope is the radioactive component used in radioligand imaging/ radioligand therapy and can either emit γ radiation for imaging (diagnostic use) or deliver targeted β− or α radiation (therapeutic use) to cancer cells.3,6
Radioligands are built with a well-defined structure composed of 4 key components.3-5
Targeting ligand
Radioisotope
Chelator
Linker
Target
Structure