STRUCTURE
Short single-stranded DNA sequence with modified nucleotides (~8-15 kDa)
Smaller SOMAmer size allows for better access to target proteins and binding sites.
Antibodies
STRUCTURE
Large, multichain protein (~150 kDa)
SOMAmer Reagents
Antibodies
PRODUCTION
Produced by biological systems, leading to natural variability
SOMAmer Reagents
PRODUCTION
Chemically synthesized, providing consistent structure
Synthetic SOMAmer production ensures batch-to-batch consistency and eliminates biological variability. Measure the same epitope every time.
Antibodies
For polyclonal antibodies, random selection through immune response leads to batch-to-batch variability
SOMAmer Reagents
Controlled selection through SELEX ensures reproducible and optimized binding characteristics
Ensures batch consistency and reproducibility.
SELECTION PROCESS
SELECTION PROCESS
Antibodies
No universal competitor to eliminate non-specific binding
SOMAmer Reagents
Uses a universal polyanionic competitor to eliminate non-specific binding
Universal polyanionic competitor during protein detection with SOMAmers prevents rebinding of transient, non-specific interactions.
Non-specific binding control
Non-specific binding control
Antibodies
High specificity; monoclonal antibodies bind a single epitope, while polyclonal antibodies bind multiple epitopes
SOMAmer Reagents
High specificity, binding to specific target epitopes
Monoclonal antibodies bind a single epitope with high specificity, while polyclonal antibodies broadly bind many epitopes.
Binding specificity
Binding specificity