Production Chemical Solutions
Process Liquid Preparation Services
Streamline process liquid/buffer manufacturing workflows by delivering fit-for-purpose solutions—ranging from ready-to-hydrate dry powder chemicals to ready-to-use process liquids. Benefit from:
Flexible specifications for chemical grade, brand, container type, and format
A global manufacturing network
Our expertise and experience
Production Chemicals and Sourcing Services
Confidently manage and source the cGMP chemicals used throughout the mRNA workflow.
Accessing a broad portfolio of cGMP chemicals
Building supply reliability through an established network of industry-leading cGMP chemical manufacturers
Optimising resources with a robust order and supply chain management infrastructure
The way forward in mRNA manufacturing.
Connect with us to bring your mRNA therapeutic workflow to commercialisation with confidence.
Questions?
Reach out to your local technical sales specialist.
E.coli fermentation
Harvest centrifugation
Lysis
UF/DF
Anion exchange chromatography
Polish chromatography
Analytical testing
Filtration
In vitro transcription (IVT)
Post IVT reactions
Affinity capture chromatography
Polish chromatography
Analytical testing
Sterile filtration
LNP encapsulation
Bulk fill
Plasmid production
mRNA production
mRNA purification
Formulation
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mRNA vaccine and therapeutic process overview
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Simplify your purification process with our innovative chromatography solutions specifically designed to improve the downstream purification of mRNA molecules.
Once the mRNA molecules have been purified, they are ready for formulation. The mRNA molecules can be complexed with the lipid reagents to mediate efficient delivery to the target cells. Bring your formulation process together seamlessly with an extensive range of standard and customised bioprocess containers, storage and fluid transfer products.
Plasmids are the building blocks needed to manufacture mRNA therapeutics. Plasmid production takes place in a microbial fermentation process and our product solutions are designed to scale up the production from development to commercial phase.
Achieve faster process development with our product solutions designed to scale production whilst isolating, purifying and extracting high quality plasmid DNA.
Achieve faster process development with our product solutions designed to scale production whilst isolating high quantity circular plasmid DNA from bacterial cells by alkaline lysis.
mRNA production using in vitro transcription (IVT) is typically performed in a bioreactor using a plasmid DNA template and appropriate quality grade nucleotides, enzymes and accessory reaction components. The IVT conditions are controlled by the bioreactor to optimize the reaction conditions and help produce the large quantities of mRNA needed for a therapeutic or vaccine.
Enter
With Thermo Fisher Scientific, you have the support to accelerate mRNA therapeutics from discovery to commercialisation with our comprehensive portfolio of products & services proven to meet critical process, scale, quality and regulatory needs.
Innovative solutions to support your mRNA therapeutics workflow
Thermo Scientific™ TruBio™ Bioprocess Automation and Control Software
Enables easy integration of process measurements and data sources powered by the DeltaV Discovery platform.
Reduced footprint.
The TruBio Software can be used across the mRNA workflow.
Thermo Scientific™ HyPerforma™ G3 Bioprocess Controller
Scalability that allows
transfer of any process from 5 L to 5,000 L and can be used throughout the mRNA workflow.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
DeltaV fully validated software 21 CFR Part 11 compliant.
Transferability of software and speed to scale-up.
Thermo Scientific™ HyPerforma™ Single-Use Fermentor (S.U.F.)
30 L and 300 L working volume with a 5:1 turndown ratio.
Thermo Scientific™ BPC designs are available with Thermo Scientific™ CX5-14 and Aegis™ 5-14 film options.
Consistent scalability from process development to production.
Small-scale and
Large-scale GMP plasmid production offering
E.coli fermentation
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Thermo Scientific™ HyPerforma™ Smartainer 3.0 systems
The Smartainer systems are stainless steel
support containers used for in-house, large-volume, liquid-handling operations. These systems have an updated design and offer multiple sizes up to 3,000 L.
Containers constructed with 304 stainless steel.
Designed to allow bottom draining from Thermo Scientific™ BPCs.
Modular system with optional accessories for increased mobility and BPC handling.
Thermo Scientific™ HyPerforma™ G3 Bioprocess Controller
Scalability that allows transfer of any process
from 5 L to 5,000 L.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
DeltaV fully validated software 21 CFR Part 11 compliant.
Transferability of software and speed to scale-up conversions when using TruBio software from research to clinical to commercial production processes.
Thermo Scientific ™ HyPerforma ™ Mixtainer Systems
Mixer solutions for resuspension, alkaline lysis and neutralisation buffers preparation to enable small scale pDNA lysis process: available at 30 L, 100L, 250L and 500 L.
Consistent scalability for a number of applications.
Fully integrated with either Thermo Scientific™ HyPerforma™ G3 Bioprocess Controllers.
Thermo Scientific™ Single-Use Mixers (S.U.M.s)
Mixer solutions for resuspension, alkaline lysis and neutralisation buffers preparation to enable large scale pDNA lysis process: available from 30L up to 5000 L.
Consistent scalability for a number of applications.
Fully integrated with either Thermo Scientific™ HyPerforma™ G3 Bioprocess Controllers, or controllers from other manufacturers.
Thermo Scientific™ Single-Use Mixers (S.U.M.s)
Mixer solutions for resuspension, alkaline lysis and neutralisation buffers preparation to enable small scale pDNA lysis process: available at 30 L, 100L, 250L and 500 L.
Consistent scalability for a number of applications.
Fully integrated with either Thermo Scientific™ HyPerforma™ G3 Bioprocess Controllers.
Thermo Scientific™ HyPerforma™ G3 Bioprocess Controller
Scalability that allows transfer of any process
from 5 L to 5,000 L.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
DeltaV fully validated software 21 CFR Part 11 compliant.
Transferability of software and speed to scale-up conversions when using TruBio software from research to clinical to commercial production processes.
Thermo Scientific™ CentriPAK™ BioProcess Container
Designed for use in the Thermo Scientific™ Sorvall™ BIOS 16 Bioprocessing Centrifuge and 6 x 2000 mL or 8 x 20 Gentle high-throughput and high-efficiency separation.
Closed system handling.
Thermo Scientific™ Sorvall™ BIOS 16 Bioprocessing Centrifuge
Designed for high quality harvesting, separation and purification bioprocessing methods that require run to run reproducibility and traceability.
Product offerings to support harvest and lysis
Harvest and lysis solution for 300 L Fermentation process
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Harvest and lysis solution for 30 L Fermentation process
Harvest centrifugation
Lysis
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Thermo Scientific ™ HyPerforma ™ Mixtainer Systems
Mixer solutions for buffer preparation to enable chromatographic plasmid DNA purification process: available at 30 L, 100L, 250L and 500 L.
Thermo Scientific™ HyPerforma™ G3 Bioprocess Controller
Scalability that allows transfer of any process
from 5 L to 5,000 L.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
DeltaV fully validated software 21 CFR Part 11 compliant.
Transferability of software and speed to scale-up conversions when using TruBio software from research to clinical to commercial production processes.
Thermo Scientific™ Single-Use Mixers (S.U.M.s)
Mixers for small scale pDNA purification process buffers and storage from 30 to 500 L sizes and 500 L – 5000L sizes for large scale pDNA purification.
Consistent scalability for a number of applications.
Fully integrated with either Thermo Scientific™ HyPerforma™ G3 Bioprocess Controllers, or controllers from other manufacturers.
Thermo Scientific™
POROS™ Benzyl Ultra Hydrophobic Interaction Chromatography (HIC) Resin
Bioprocess high-performance resin engineered for improved impurity removal during large-scale downstream purification of biomolecules.
This unique resin provides high resolution and capacity while maintaining excellent pressure flow characteristics, helping increase productivity.
Available as prepacked columns for small scale purification or lose resin for large scale purification.
Thermo Scientific™ POROS™ Anion Exchange Resin
Designed for high-dynamic binding capacity over a range of pH and conductivity conditions.
Increasing process development flexibility and manufacturing throughput.
Resin available as prepacked columns for small scale purification or lose resin for large scale purification.
Product offerings to support plasmid purification
UF/DF
Anion exchange chromatography
Polish chromatography
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Applied Biosystems™
QuantStudio™ 5 and 7500 Fast Real-Time PCR System
A streamlined workflow enables validation, minimize hands-on time, and improve overall productivity.
AccuSEQ software integrates with Applied Biosystems™ QuantStudio™ 5 and 7500 Fast real-time PCR instruments.
Worldwide support network, helps enable21 CFR Part 11 compliance.
Applied Biosystems™
Pharma KingFisher™ Flex 96 Deep-Well Magnetic Particle Processor
High-throughput, automated approaches offer the advantage of quickly processing many samples, with a high degree of reproducibility.
This technology has been incorporated into industry-standard Applied Biosystems™PrepSEQ™ Nucleic Acid Extraction Kit, resDNASEQ™ Quantitative DNA kits, and ProteinSEQ™ kits, and is easily adaptable to a 96-well plate format.
Applied Biosystems™ resDNASEQ™ Quantitative Plasmid DNA - Kanamycin Resistance Gene Kit
Designed to quantitate residual plasmid DNA with any common alleles of kanamycin-resistance gene.
Highly sensitive quantitation through innovative DNA-free master mix.
Applied Biosystems™ resDNASEQ™ Quantitative E.coli DNA kit
Highly sensitive quantitation of host E.coli DNA using proven TaqMan® real-time qPCR technology.
Manual and automated sample preparation, optimized for quantitative recovery from complex sample matrices.
Innovative Solutions to support analytical testing in mRNA manufacturing
Analytical testing
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Enter
With Thermo Fisher Scientific, you have the support to accelerate mRNA therapeutics from discovery to commercialisation with our comprehensive portfolio of products & services proven to meet critical process, scale, quality and regulatory needs.
Innovative solutions to support your mRNA therapeutics workflow
Thermo Scientific™
HyPerforma™
DynaDrive Single-Use Bioreactor
This HyPerforma DynaDrive S.U.B. and its cube-shaped tank and unique stirred-tank design utilizes a novel drive train with multiple impellers. The mixing capability of the bioreactor is superior, which enables optimal mixing.
Turndown ration 10:1: Working volumes from 5L to 50L.
Thermo Scientific™
HyPerforma™
Single-Use Bioreactor
Unique proprietary mixing system that enables conventional overhead mixing while maintaining sterility and integrity of the S.U.B. BioProcess Container (BPC).
Turndown ratio 5:1: Working volumes from 10L to 50L.
Thermo Scientific™
TheraPure™ and TheraPure™ Plus enzymes and nucleotides
The G3 core controller can control most scale with ease brands of single-use or autoclavable bioreactors or fermentors ≤50 L in size.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
Capability of taking non-GMP research and process development applications to GMP commercial.
Thermo Scientific™
HyPerforma™ Rocker Bioreactor
Rocking motion is customizable to your specific workflow.
Quick, simple setup with a HyPerforma Bioprocess Controller and TruBio software.
Thermo Scientific™ BPC designs are available with Thermo Scientific™ CX5-14 and Aegis™ 5-14 film options.
Working volume 1 L – 25 L.
Thermo Scientific™ TruBio™ Bioprocess Automation and Control Software
Enables easy integration of process measurements and data sources powered by the DeltaV Discovery platform.
Reduced footprint.
Thermo Scientific™ HyPerforma™ G3 Bioprocess Controller
Scalability that allows transfer of any process from 5 L to 5,000 L.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
DeltaV fully validated software 21 CFR Part 11 compliant.
Transferability of software and speed to scale-up.
Thermo Scientific™
HyPerforma™ Glass Bioreactors
Easy operation, rapid assembly, and are manufactured with the highest technology and design standards.
These benchtop glass bioreactors are developed to ensure sterile processes and minimize lost batches.
Hyperforma™ Glass Bioreactors are available in 1, 3, 7, and 15 L sizes: Working volumes from 0.3 L to 15L.
Autoclavable.
Heat jacket and optional cooling.
Thermo Scientific™ TheraPure™ GMP enzymes and nucleotides
Provide tightly controlled purity standards
Restriction enzymes, RNA polymerase, RNase Inhibitor, inorganic pyrophosphatase, capping enzymes, Poly(A) polymerase, Proteinase K and DNase I, nucleotides and modified nucleotides
GMP grade materials for mRNA production include: nucleotides, restriction enzymes, T7 RNA polymerase, RNase inhibitor, inorganic pyrophosphatase and DNase I
Thermo Scientific™
HyPerforma™ Rocker Bioreactor
Rocking motion is customizable to your specific workflow.
Quick, simple setup with a HyPerforma Bioprocess Controller and TruBio software.
Thermo Scientific™ BPC designs are available with Thermo Scientific™ CX5-14 and Aegis™ 5-14 film options.
Working volume 1 L – 25 L.
Thermo Scientific™ TruBio™ Bioprocess Automation and Control Software
Enables easy integration of process measurements and data sources powered by the DeltaV Discovery platform.
Reduced footprint.
Thermo Scientific™ HyPerforma™ GXCore Bioprocess Controller
This controller offers a
compact design—enabling
users to easily scale-up and adapt to suit specific process and application goals.
Scalability: ≤15 L.
Reduced footprint and stackable.
Auxiliary connections to allow future expansion and/or additional capabilities.
Open-architecture capabilities to integrate with vessels from other suppliers.
Product offerings to support large scale
In Vitro Transcription in single use systems
Product offerings to support process development and small scale in vitro mRNA transcription
In vitro transcription (IVT)
Post IVT reactions
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Thermo Scientific ™ HyPerforma ™ Mixtainer Systems
Mixer solutions for buffer preparation to enable chromatographic plasmid DNA purification process: available at 30 L, 100L, 250L and 500 L.
Thermo Scientific™ TruBio™ Bioprocess Automation and Control Software
Enables easy integration of process measurements and data sources powered by the DeltaV Discovery platform.
Reduced footprint.
Thermo Scientific™ Single-Use Mixers (S.U.M.s)
For both small and large scale mRNA purification process available in 30, 100, 200 L sizes.
Consistent scalability for a number of applications.
Fully integrated with either Thermo Scientific™ HyPerforma™ G3 Bioprocess Controllers, or controllers from other manufacturers.
Thermo Scientific™
POROS™ Benzyl Ultra Hydrophobic Interaction Chromatography (HIC) Resin
Bioprocess high-performance resin engineered for improved impurity removal during large-scale downstream purification of biomolecules.
This unique resin provides high resolution and capacity while maintaining excellent pressure flow characteristics, helping increase productivity.
Thermo Scientific™
POROS™ Oligo (dT)25 Affinity Resin
Oligo dT 25 is designed for the purification and isolation of mRNA from in vitro transcription (IVT) manufacturing processes.
The resin effectively separates mRNA from components of the transcription reaction process, such as enzymes and plasmid DNA.
Excellent scalability.
Non-animal derived.
Product offerings to support mRNA purification
Affinity capture chromatography
Polish chromatography
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Patheon by Thermo Fisher Scientific
Offer solutions that are flexible, comprehensive fill and finish services that comply with current regulatory and quality requirement.
Thermo Scientific ™ HyPerforma ™ Mixtainer Systems
Mixer solutions for formulation and storage buffers available at 30 L, 100L, 250L and 500 L.
Product offerings to support Formulation /
Fill & Finish
Sterile filtration
LNP encapsulation
Bulk fill
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Applied Biosystems™
AccuSEQ™ Real-Time PCR Detection Software
Thermo Scientific™
HyPerforma™
Single-Use Mixers 500L & 1000L
Large scale production process 500, 1000 and 2000 L.
Consistent scalability for a number of applications.
Fully integrated with either Thermo Scientific™ HyPerforma™ G3 Bioprocess Controllers.
Thermo Scientific™ BPC designs are available with Thermo Scientific™ CX5-14 and Aegis™ 5-14 film options.
Thermo Scientific™ TruBio™ Bioprocess Automation and Control Software
Enables easy integration of process measurements and data sources powered by the DeltaV Discovery platform.
Reduced footprint.
Thermo Scientific™
HyPerforma™ Glass Bioreactors
Easy operation, rapid
assembly, and are manufactured with the highest technology and design standards.
These benchtop glass bioreactors are developed to ensure sterile processes and minimize lost batches.
HyPerforma™ Glass Bioreactors are available in 1, 3, 7, and 15 L sizes: Working volumes from 0.3 L to 15L.
Autoclavable.
Heat jacket and optional cooling.
Gibco™ Bacto CD™ Supreme Fermentation Production Medium (FPM)
Chemically defined medium for microbial fermentation.
Reduce lot-to-lot performance variability with a 100% chemically defined formulation.
Eliminate risk of bacteriophage and BSE/TSE contamination.
Ideal for plasmid production and scalable format to meet your development needs.
Thermo Scientific™ HyPerforma™ Single-Use Mixers
Single-Use Mixer (S.U.M.s) with touchscreen console is designed using proven mixer platform principles and used for upstream and downstream mixing applications.
Capacity from 30L to 300L to accommodate Fermentation Medium preparation.
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Scalability that allows transfer of any process
from 5 L to 5,000 L and
can be used throughout
the mRNA workflow.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
DeltaV fully validated software 21 CFR Part
11 compliant.
Transferability of software and speed to scale-up.
Scalability that allows transfer of any process
from 5 L to 5,000 L and
can be used throughout
the mRNA workflow.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
DeltaV fully validated software 21 CFR Part
11 compliant.
Transferability of software and speed to scale-up.
Scalability that allows transfer of any process
from 5 L to 5,000 L and
can be used throughout
the mRNA workflow.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
DeltaV fully validated software 21 CFR Part
11 compliant.
Transferability of software and speed to scale-up.
Scalability that allows transfer of any process
from 5 L to 5,000 L and
can be used throughout
the mRNA workflow.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
DeltaV fully validated software 21 CFR Part
11 compliant.
Transferability of software and speed to scale-up.
Easy operation, rapid
assembly, and are
manufactured with the highest technology and design standards.
These benchtop glass bioreactors are developed to ensure sterile processes and minimize lost batches.
HyPerforma™ Glass Bioreactors are available in 1, 3, 7, and 15 L sizes: Working volumes from 0.3 L to 15L.
Autoclavable.
Heat jacket and optional cooling.
Easy operation, rapid
assembly, and are
manufactured with the highest technology and design standards.
These benchtop glass bioreactors are developed to ensure sterile processes and minimize lost batches.
HyPerforma™ Glass Bioreactors are available in 1, 3, 7, and 15 L sizes: Working volumes from 0.3 L to 15L.
Autoclavable.
Heat jacket and optional cooling.
Easy operation, rapid
assembly, and are
manufactured with the highest technology and design standards.
These benchtop glass bioreactors are developed to ensure sterile processes and minimize lost batches.
HyPerforma™ Glass Bioreactors are available in 1, 3, 7, and 15 L sizes: Working volumes from 0.3 L to 15L.
Autoclavable.
Heat jacket and optional cooling.
Easy operation, rapid
assembly, and are
manufactured with the highest technology and design standards.
These benchtop glass bioreactors are developed to ensure sterile processes and minimize lost batches.
HyPerforma™ Glass Bioreactors are available in 1, 3, 7, and 15 L sizes: Working volumes from 0.3 L to 15L.
Autoclavable.
Heat jacket and optional cooling.
Easy operation, rapid
assembly, and are
manufactured with the highest technology and design standards.
These benchtop glass bioreactors are developed to ensure sterile processes and minimize lost batches.
HyPerforma™ Glass Bioreactors are available in 1, 3, 7, and 15 L sizes: Working volumes from 0.3 L to 15L.
Autoclavable.
Heat jacket and optional cooling.
Scalability that allows transfer of any process
from 5 L to 5,000 L.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
DeltaV fully validated software 21 CFR Part 11 compliant.
Transferability of software and speed to scale-up conversions when using TruBio software from research to clinical to commercial production processes.
Scalability that allows transfer of any process
from 5 L to 5,000 L.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
DeltaV fully validated software 21 CFR Part 11 compliant.
Transferability of software and speed to scale-up conversions when using TruBio software from research to clinical to commercial production processes.
Scalability that allows transfer of any process
from 5 L to 5,000 L.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
DeltaV fully validated software 21 CFR Part 11 compliant.
Transferability of software and speed to scale-up conversions when using TruBio software from research to clinical to commercial production processes.
Scalability that allows transfer of any process
from 5 L to 5,000 L.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
DeltaV fully validated software 21 CFR Part 11 compliant.
Transferability of software and speed to scale-up conversions when using TruBio software from research to clinical to commercial production processes.
Scalability that allows transfer of any process
from 5 L to 5,000 L.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
DeltaV fully validated software 21 CFR Part 11 compliant.
Transferability of software and speed to scale-up conversions when using TruBio software from research to clinical to commercial production processes.
Scalability that allows transfer of any process
from 5 L to 5,000 L.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
DeltaV fully validated software 21 CFR Part 11 compliant.
Transferability of software and speed to scale-up conversions when using TruBio software from research to clinical to commercial production processes.
Scalability that allows transfer of any process
from 5 L to 5,000 L.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
DeltaV fully validated software 21 CFR Part 11 compliant.
Transferability of software and speed to scale-up conversions when using TruBio software from research to clinical to commercial production processes.
Scalability that allows transfer of any process
from 5 L to 5,000 L.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
DeltaV fully validated software 21 CFR Part 11 compliant.
Transferability of software and speed to scale-up conversions when using TruBio software from research to clinical to commercial production processes.
The Smartainer systems are stainless steel
support containers used for in-house, large-volume, liquid-handling operations. These systems have an updated design and offer multiple sizes up to 3,000 L.
Containers constructed with 304 stainless steel.
Designed to allow bottom draining from Thermo Scientific™ BPCs.
Modular system with optional accessories for increased mobility and BPC handling.
The Smartainer systems are stainless steel
support containers used for in-house, large-volume, liquid-handling operations. These systems have an updated design and offer multiple sizes up to 3,000 L.
Containers constructed with 304 stainless steel.
Designed to allow bottom draining from Thermo Scientific™ BPCs.
Modular system with optional accessories for increased mobility and BPC handling.
The Smartainer systems are stainless steel
support containers used for in-house, large-volume, liquid-handling operations. These systems have an updated design and offer multiple sizes up to 3,000 L.
Containers constructed with 304 stainless steel.
Designed to allow bottom draining from Thermo Scientific™ BPCs.
Modular system with optional accessories for increased mobility and BPC handling.
The Smartainer systems are stainless steel
support containers used for in-house, large-volume, liquid-handling operations. These systems have an updated design and offer multiple sizes up to 3,000 L.
Containers constructed with 304 stainless steel.
Designed to allow bottom draining from Thermo Scientific™ BPCs.
Modular system with optional accessories for increased mobility and BPC handling.
Mixers for small scale pDNA purification process buffers and storage from 30 to 500 L sizes and 500 L – 5000L sizes for large scale pDNA purification.
Consistent scalability for
a number of applications.
Fully integrated with either Thermo Scientific™ HyPerforma™ G3 Bioprocess Controllers,
or controllers from other manufacturers.
Mixers for small scale pDNA purification process buffers and storage from 30 to 500 L sizes and 500 L – 5000L sizes for large scale pDNA purification.
Consistent scalability for
a number of applications.
Fully integrated with either Thermo Scientific™ HyPerforma™ G3 Bioprocess Controllers,
or controllers from other manufacturers.
Mixers for small scale pDNA purification process buffers and storage from 30 to 500 L sizes and 500 L – 5000L sizes for large scale pDNA purification.
Consistent scalability for
a number of applications.
Fully integrated with either Thermo Scientific™ HyPerforma™ G3 Bioprocess Controllers,
or controllers from other manufacturers.
Scalability that allows transfer of any process
from 5 L to 5,000 L.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
DeltaV fully validated software 21 CFR Part 11 compliant.
Transferability of software and speed to scale-up conversions when using TruBio software from research to clinical to commercial production processes.
Scalability that allows transfer of any process
from 5 L to 5,000 L.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
DeltaV fully validated software 21 CFR Part 11 compliant.
Transferability of software and speed to scale-up conversions when using TruBio software from research to clinical to commercial production processes.
Scalability that allows transfer of any process
from 5 L to 5,000 L.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
DeltaV fully validated software 21 CFR Part 11 compliant.
Transferability of software and speed to scale-up conversions when using TruBio software from research to clinical to commercial production processes.
Scalability that allows transfer of any process
from 5 L to 5,000 L.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
DeltaV fully validated software 21 CFR Part 11 compliant.
Transferability of software and speed to scale-up conversions when using TruBio software from research to clinical to commercial production processes.
Rocking motion is customizable to your
specific workflow.
Quick, simple setup with
a HyPerforma Bioprocess Controller and TruBio software.
Thermo Scientific™ BPC designs are available
with Thermo Scientific™ CX5-14 and Aegis™ 5-14 film options.
Working volume 1 L – 25 L.
Rocking motion is customizable to your
specific workflow.
Quick, simple setup with
a HyPerforma Bioprocess Controller and TruBio software.
Thermo Scientific™ BPC designs are available
with Thermo Scientific™ CX5-14 and Aegis™ 5-14 film options.
Working volume 1 L – 25 L.
Rocking motion is customizable to your
specific workflow.
Quick, simple setup with
a HyPerforma Bioprocess Controller and TruBio software.
Thermo Scientific™ BPC designs are available
with Thermo Scientific™ CX5-14 and Aegis™ 5-14 film options.
Working volume 1 L – 25 L.
Rocking motion is customizable to your
specific workflow.
Quick, simple setup with
a HyPerforma Bioprocess Controller and TruBio software.
Thermo Scientific™ BPC designs are available
with Thermo Scientific™ CX5-14 and Aegis™ 5-14 film options.
Working volume 1 L – 25 L.
This controller offers a
compact design—enabling
users to easily scale-up and adapt to suit specific process and application goals.
Scalability: ≤15 L.
Reduced footprint and stackable.
Auxiliary connections to allow future expansion and/or additional capabilities.
Open-architecture capabilities to integrate with vessels from other suppliers.
This controller offers a
compact design—enabling
users to easily scale-up and adapt to suit specific process and application goals.
Scalability: ≤15 L.
Reduced footprint and stackable.
Auxiliary connections to allow future expansion and/or additional capabilities.
Open-architecture capabilities to integrate with vessels from other suppliers.
This controller offers a
compact design—enabling
users to easily scale-up and adapt to suit specific process and application goals.
Scalability: ≤15 L.
Reduced footprint and stackable.
Auxiliary connections to allow future expansion and/or additional capabilities.
Open-architecture capabilities to integrate with vessels from other suppliers.
This controller offers a
compact design—enabling
users to easily scale-up and adapt to suit specific process and application goals.
Scalability: ≤15 L.
Reduced footprint and stackable.
Auxiliary connections to allow future expansion and/or additional capabilities.
Open-architecture capabilities to integrate with vessels from other suppliers.
This controller offers a
compact design—enabling
users to easily scale-up and adapt to suit specific process and application goals.
Scalability: ≤15 L.
Reduced footprint and stackable.
Auxiliary connections to allow future expansion and/or additional capabilities.
Open-architecture capabilities to integrate with vessels from other suppliers.
Rocking motion
is customizable to
your specific workflow.
Quick, simple setup with
a HyPerforma Bioprocess Controller and TruBio software.
Thermo Scientific™ BPC designs are available with Thermo Scientific™ CX5-14 and Aegis™ 5-14 film options.
Working volume 1 L – 25 L.
Rocking motion
is customizable to
your specific workflow.
Quick, simple setup with
a HyPerforma Bioprocess Controller and TruBio software.
Thermo Scientific™ BPC designs are available with Thermo Scientific™ CX5-14 and Aegis™ 5-14 film options.
Working volume 1 L – 25 L.
Rocking motion
is customizable to
your specific workflow.
Quick, simple setup with
a HyPerforma Bioprocess Controller and TruBio software.
Thermo Scientific™ BPC designs are available with Thermo Scientific™ CX5-14 and Aegis™ 5-14 film options.
Working volume 1 L – 25 L.
Rocking motion
is customizable to
your specific workflow.
Quick, simple setup with
a HyPerforma Bioprocess Controller and TruBio software.
Thermo Scientific™ BPC designs are available with Thermo Scientific™ CX5-14 and Aegis™ 5-14 film options.
Working volume 1 L – 25 L.
Provide tightly controlled purity standards.
Enzymes include restriction enzymes, RNA polymerases, RNase inhibitors, inorganic pyrophosphatase, capping enzymes, Poly(A)Polymerase, Proteinase K I and DNase.
Nucleotides and modified nucleotides" to " GMP grade materials for mRNA production including:
Nucleotides, modified nucleotides, restriction enzymes T7 RNA polymerase, DNase I.
Provide tightly controlled purity standards.
Enzymes include restriction enzymes, RNA polymerases, RNase inhibitors, inorganic pyrophosphatase, capping enzymes, Poly(A)Polymerase, Proteinase K I and DNase.
Nucleotides and modified nucleotides" to " GMP grade materials for mRNA production including:
Nucleotides, modified nucleotides, restriction enzymes T7 RNA polymerase, DNase I.
Provide tightly controlled purity standards.
Enzymes include restriction enzymes, RNA polymerases, RNase inhibitors, inorganic pyrophosphatase, capping enzymes, Poly(A)Polymerase, Proteinase K I and DNase.
Nucleotides and modified nucleotides" to " GMP grade materials for mRNA production including:
Nucleotides, modified nucleotides, restriction enzymes T7 RNA polymerase, DNase I.
Easy operation, rapid assembly, and are manufactured with the highest technology and design standards.
These benchtop glass bioreactors are developed to ensure sterile processes and minimize lost batches.
Hyperforma™ Glass Bioreactors are available in 1, 3, 7, and 15 L sizes: Working volumes from 0.3 L to 15L.
Autoclavable.
Heat jacket and optional cooling.
Easy operation, rapid assembly, and are manufactured with the highest technology and design standards.
These benchtop glass bioreactors are developed to ensure sterile processes and minimize lost batches.
Hyperforma™ Glass Bioreactors are available in 1, 3, 7, and 15 L sizes: Working volumes from 0.3 L to 15L.
Autoclavable.
Heat jacket and optional cooling.
Easy operation, rapid assembly, and are manufactured with the highest technology and design standards.
These benchtop glass bioreactors are developed to ensure sterile processes and minimize lost batches.
Hyperforma™ Glass Bioreactors are available in 1, 3, 7, and 15 L sizes: Working volumes from 0.3 L to 15L.
Autoclavable.
Heat jacket and optional cooling.
Easy operation, rapid assembly, and are manufactured with the highest technology and design standards.
These benchtop glass bioreactors are developed to ensure sterile processes and minimize lost batches.
Hyperforma™ Glass Bioreactors are available in 1, 3, 7, and 15 L sizes: Working volumes from 0.3 L to 15L.
Autoclavable.
Heat jacket and optional cooling.
Easy operation, rapid assembly, and are manufactured with the highest technology and design standards.
These benchtop glass bioreactors are developed to ensure sterile processes and minimize lost batches.
Hyperforma™ Glass Bioreactors are available in 1, 3, 7, and 15 L sizes: Working volumes from 0.3 L to 15L.
Autoclavable.
Heat jacket and optional cooling.
Harvest centrifugation
Lysis
UF/DF
Anion exchange chromatography
Polish chromatography
Analytical testing
Capability of taking non-GMP research and process development applications
to GMP commercial.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
The G3 core controller
can control most scale with ease brands of single-use
or autoclavable bioreactors or fermentors ≤50 L in size.
Thermo Scientific™
TheraPure™ and TheraPure™ Plus enzymes and nucleotides
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30 L and 300 L working volume with a 5:1 turndown ratio.
Thermo Scientific™ BPC designs are available with Thermo Scientific™
CX5-14 and Aegis™
5-14 film options.
Consistent scalability
from process development to production.
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Mixer solutions for resuspension, alkaline lysis and neutralisation buffers preparation to enable small scale pDNA lysis process: available at 30 L, 100L, 250L and 500 L.
Consistent scalability
for a number of applications.
Fully integrated with either Thermo Scientific™ HyPerforma™ G3 Bioprocess Controllers.
Mixer solutions for resuspension, alkaline lysis and neutralisation buffers preparation to enable small scale pDNA lysis process: available at 30 L, 100L, 250L and 500 L.
Consistent scalability
for a number of applications.
Fully integrated with either Thermo Scientific™ HyPerforma™ G3 Bioprocess Controllers.
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Mixer solutions for resuspension, alkaline
lysis and neutralisation buffers preparation
to enable large scale pDNA lysis process: available
from 30L up to 5000 L.
Consistent scalability for
a number of applications.
Fully integrated with either Thermo Scientific™ HyPerforma™ G3 Bioprocess Controllers,
or controllers from other manufacturers.
Mixer solutions for resuspension, alkaline
lysis and neutralisation buffers preparation
to enable large scale pDNA lysis process: available
from 30L up to 5000 L.
Consistent scalability for
a number of applications.
Fully integrated with either Thermo Scientific™ HyPerforma™ G3 Bioprocess Controllers,
or controllers from other manufacturers.
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Mixer solutions for resuspension, alkaline lysis
and neutralisation buffers preparation to enable
small scale pDNA lysis process: available at 30 L, 100L, 250L and 500 L.
Consistent scalability for
a number of applications.
Fully integrated with either Thermo Scientific™ HyPerforma™ G3 Bioprocess Controllers.
Mixer solutions for resuspension, alkaline lysis
and neutralisation buffers preparation to enable
small scale pDNA lysis process: available at 30 L, 100L, 250L and 500 L.
Consistent scalability for
a number of applications.
Fully integrated with either Thermo Scientific™ HyPerforma™ G3 Bioprocess Controllers.
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Scalability that allows transfer of any process
from 5 L to 5,000 L.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
DeltaV fully validated software 21 CFR Part
11 compliant.
Transferability of software and speed to scale-up.
Scalability that allows transfer of any process
from 5 L to 5,000 L.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
DeltaV fully validated software 21 CFR Part
11 compliant.
Transferability of software and speed to scale-up.
Scalability that allows transfer of any process
from 5 L to 5,000 L.
Utilized Thermo Scientific TruBio Bioprocess Automation and Control Software.
DeltaV fully validated software 21 CFR Part
11 compliant.
Transferability of software and speed to scale-up.
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This HyPerforma DynaDrive S.U.B. and its cube-shaped tank and unique stirred-tank design utilizes a novel drive train with multiple impellers. The mixing capability of the bioreactor is superior, which enables optimal mixing.
Turndown ration 10:1: Working volumes
from 5L to 50L.
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Oligo dT 25 is designed
for the purification and isolation of mRNA from
in vitro transcription (IVT) manufacturing processes.
The resin effectively separates mRNA from components of the transcription reaction process, such as enzymes and plasmid DNA.
Excellent scalability.
Non-animal derived.
Oligo dT 25 is designed
for the purification and isolation of mRNA from
in vitro transcription (IVT) manufacturing processes.
The resin effectively separates mRNA from components of the transcription reaction process, such as enzymes and plasmid DNA.
Excellent scalability.
Non-animal derived.
Oligo dT 25 is designed
for the purification and isolation of mRNA from
in vitro transcription (IVT) manufacturing processes.
The resin effectively separates mRNA from components of the transcription reaction process, such as enzymes and plasmid DNA.
Excellent scalability.
Non-animal derived.
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For both small and large scale mRNA purification process available in 30,
100, 200 L sizes.
Consistent scalability for
a number of applications.
Fully integrated with either Thermo Scientific™ HyPerforma™ G3 Bioprocess Controllers,
or controllers from other manufacturers.
For both small and large scale mRNA purification process available in 30,
100, 200 L sizes.
Consistent scalability for
a number of applications.
Fully integrated with either Thermo Scientific™ HyPerforma™ G3 Bioprocess Controllers,
or controllers from other manufacturers.
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Large scale production process 500, 1000
and 2000 L.
Consistent scalability for
a number of applications.
Fully integrated with either Thermo Scientific™ HyPerforma™ G3 Bioprocess Controllers.
Thermo Scientific™ BPC designs are available with Thermo Scientific™ CX5-14 and Aegis™ 5-14 filmions.
Large scale production process 500, 1000
and 2000 L.
Consistent scalability for
a number of applications.
Fully integrated with either Thermo Scientific™ HyPerforma™ G3 Bioprocess Controllers.
Thermo Scientific™ BPC designs are available with Thermo Scientific™ CX5-14 and Aegis™ 5-14 filmions.
Large scale production process 500, 1000
and 2000 L.
Consistent scalability for
a number of applications.
Fully integrated with either Thermo Scientific™ HyPerforma™ G3 Bioprocess Controllers.
Thermo Scientific™ BPC designs are available with Thermo Scientific™ CX5-14 and Aegis™ 5-14 filmions.
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