Any Data.
UBC’s Evidence Engine is an end-to-end data architecture solution which provides comprehensive data ingestion, aggregation, and warehousing for your project. Trace the patient journey, consolidate registry and clinical site data, identify payer and HCP behavior, and even enhance the data with healthcare marketplace real-world datasets.
To link patients across all internal data sources, as well as external third party sources, UBC has partnered with a data management firm that employs cutting-edge, matching algorithms to assign each patient their own distinct Master Token.
ELECTRONIC
DATA CAPTURE
Electronic Health Record SYSTEM
PHARMACOVIGILANCE PLATFORM
Pharmacy
System
REMS Platform
Patient Support
Services Systems
Site / Physician
Registries / Consortium
Patient
Data Exchange /
Markets
holistic Patient Journey
Health Data Interface /
Exchange
By being able to obtain a subject's historical, current, and future EHR data via batch or real time feed, the Evidence Engine speeds the data collection process and saves a sponsor money in greatly reducing the human involvement required to capture data points on a subject.
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Electronic Health
Records
Data Contributors
Patient Reported Outcome (PRO)
LABORATORY / BIOMARKER RESULTS
Clinical
Subject Data
Genetic Lab Results
Data Types
Top-tier, fully customizable data capture tool utilized to manage all patients in a clinical registry/study, capture all data points, and track all activities performed against the registry data.
Electronic Data Capture
The Evidence Engine integrates PRO results as a registry/study source and interface that allows for batch or real-time collection.
The Evidence Engine allows for the collection of Smart Device data at the same time a patient is completing a PRO, integrating it into a single data point to further enhance the PRO results.
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Patient Reported Outcome (PRO)
Serves as an excellent source of potential patients in REMS and Clinical Registries/Studies by flagging patients who recorded certain specific values in lab tests.
Batch collection of lab test results support retrospective studies data collection, verification and gap fill for prospective studies and registries, the streamlining of research and documentation of PV cases, and enhanced patient support for nursing services.
With the use of the patient master token process, sponsors can purchase only the data belonging to their subjects. Gone are the days of needing to buy entire lab databases for data on only a few thousand subjects.
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LABORATORY / BIOMARKER RESULTS
An excellent source of potential patients in REMS and Clinical Registries/Studies by flagging patients who tested positive for certain genetic conditions.
Batch collection of genetic test results to support retrospective data collection,
verification and gap fill, enrichment for prospective studies and registries, streamline research and documentation of PV cases and enhanced patient support for nursing services.
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Genetic LAB Results
Electronic Health Records
The Evidence Engine’s EHR system interface provides the capability to connect to all major network systems for batch or real time data transfers.
The Evidence Engine’s event engine allows for the ability to push notification and request for information directly into a patient medical record to reduce the burden on the sites and improve the patients' study experience.
ELECTRONIC HEALTH RECORD System
DISTRIBUTION / WHOLESALER
Whether it be extracting data from our internal pharmacy management system, or performing data exchanges with the leading specialty pharmacies, UBC has extensive experience directly exchanging a patient's pharm acy data.
The Evidence Engine offers bidirectional data exchanges with all major pharmacy management systems. The data exchange can be either batch processing or real time direct integration.
Pharmacy System
Though the linkage of patients, data studies and registries can obtain drug dosage and shipment information from external data markets as well as internal UBC applications to track drug shipments for patients. This saves sites the burden of entering the information.
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DISTRIBUTION /
WHOLESALER
Patient Access Services (PAS) Patient Data
Patient Charts
Clinical
Subject Data
Best-in-class application developed for the rapid creation and configuration of a REMS program. Provides documentation of all patients particating in the REMS as well as all data points designed to be captured during the program.
REMS PLatform
DISTRIBUTION / WHOLESALER
If a clinical sponsor also utilizes UBC for their Patient Access solutions, the Evidence Engine can serve as a source of potential subjects for a registry, study, or REMS program.
Through utilization of Master Token ID for Patient Access patients, the Evidence Engine can determine if the Patient Access patient is a subject in a study or registry.
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Patient Access
Patient Data
Ability to provide advanced analytics on all forms of patient interaction notes no matter
the application or service line.
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Patient Charts
Patient Charts
Customer Relationship Management (CRM) system fully customized to meet all aspects of Patient Access Programs including prescription approvals, drug shipments, nursing notes, and patient assistance approval.
Patient Access Systems
Patient Charts
Customized program workflows and data points built on Argus are utilized to track all PV program activity including all reported events, regulatory filings, and all notes and entries captured during the processing of a PV case.
PHARMACOVIGILANCE PLATFORM
Clinical
Subject Data
Health System / Network
FoundationS / External Partners
Through strategic partnerships, the Evidence Engine offers the ability to directly interface the health data exchanges for all major health networks. These interfaces allow the receipt of historical or current data via batch delivery or real time interface.
Health System / Network
Electronic Health Records
Pharmacy / Medical Claims
LABORATORY / BIOMARKER RESULTS
Clinical
Subject Data
Genetic Lab Results
Registry Data
Excellent source of potential patients in REMS and Clinical Registries/Studies through flagging patients taking specific drugs or meeting specific
medical conditions.
With the patient master token process sponsors can purchase only the data belonging to their subjects. Gone are the days of buying entire Claims Databases for data on only a few thousand subjects.
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Pharmacy /
Medical Claims
Excellent source of potential patients in REMS and Clinical Registries/Studies through flagging patients who tested positive for certain genetic conditions.
Batch collection of genetic test results to support retrospective studies data collection, verification and gap fill for prospective studies and registries, streamline research and documentation of PV cases and enhanced patient support for nursing services.
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Registry Data
Through UBC, the Evidence Engine
has access to to over 20 billion transactions from 300 million distinct patients sourced by 50 different data providers.
The Evidence Engine’s Master Token ID allows for linkage to all RWD specific to the subject. This allows for
targeted acquisition of RWD. Gone are the days of purchasing millions of record databases to integrate data for only a few subjects.
FoundationS / External Partners
LABORATORY / BIOMARKER RESULTS
Clinical
Subject Data
CONSUMER BEHAVIOR/PURCHASE PATTERN DATA
Registry Data
Ability to leverage consumer product purchase patterns to enhance research through subject patient product correlation
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CONSUMER BEHAVIOR / PURCHASE PATTERN DATA
ELECTRONIC
DATA CAPTURE
Device Wearable (IOT)
REMS Platform
Patient Support
Services Systems
Stragetic partnerships allow the Evidence Engine the ability to pull data from any smart device that allows for data export either real time or in batches.
Full integration with wide range of ePRO vendors to allow for batch and near real time receipt of a patient’s PRO results.
The Evidence Engine allows for the real time capture of data off a smart device at the same moment of a PRO submission.
DEVICE / WEARABLE (IOT)
Modality
Patient Reported Outcome (PRO)
Clinical
Subject Data
Data Types
Data Types
Data Types
Data Types
Data Types
Data Types
Data Types
Data Types
Identity Master
De-Identification
Tokenization / Linkage
To ensure a patient’s identity is never disclosed, the following standards are put in place:
Patient Privacy Policies
No Personal Health Information (PHI) is stored in The Evidence Engine data warehouse)
People who have access to the warehouse and the Master Token ID for a patient are not able to access patient PHI.
People who have access to a patient's PHI are not provided access to the patient’s master token ID.
A third party privacy consultant has certified UBC's policies and procedures.
The ability to match patients across all data sources also allows The Evidence Engine to ensure complete de-duplication of patient master records and transactions in all processes surrounding processes.
By utilizing the patient’s master ID, The Evidence Engine is able to filter out real world data (RWD) to only the transactions belonging to the subjects in the specific program. This saves sponsors money by only buying RWD records that align with the patients in their programs.
Matching algorithm results in a 99.998% patient accuracy match rate
Subject Personal Health Information (PHI) de-Identified before leaving sites.
De-identification Process encrypts PHI in a manner that the patient is still able to be uniquely identifiable, without disclosing any personal patient information.
De-ID process ensures compliance with all privacy regulations (HIPAA, GDPR, CCPA).
Specialty Pharmacy
Pharma Cross Product Program Data
Patient Support
Access Systems
Direct ParTner Connect
PHARMACOVIGILANCE PLATFORM
Pharmacy
System
ELECTRONIC
DATA CAPTURE
Health System / Network
FoundationS / External Partners
The Evidence Engine
framework allows for rapid evaluation and integration of any external data source, of any size, from any source, at any defined frequency laid out by the program sponsors,
including real time.
Direct Partner Connect
Clinical
Subject Data
LABORATORY / BIOMARKER RESULTS
DISTRIBUTION / WHOLESALER
Data Types
Pharmacy / Medical Claims
Genetic Lab Results
ELECTRONIC
DATA CAPTURE
Health System / Network
FoundationS / External Partners
Direct ParTner Connect
Patient Support
Services Systems
Pharmacy
System
Patient Support
Services Systems
Pharmacy
System
REMS Platform
Pharmacy / Medical Claims
DISTRIBUTION / WHOLESALER
Patient Access Services (PAS) Patient Data
DISTRIBUTION / WHOLESALER
PHARMACOVIGILANCE PLATFORM
REMS Platform
Anywhere.
Anytime.
Data Processing
Data Architecture
Data Processing
Standard Model
Event Processing
Master Data /
Data Cleaning
The Evidence Engine provides the ability for receipt and delivery of data in any format, from any provider, at any time, and any size. These processes can be batched on a defined schedule or real-time exchange.
Guarantee that all data sets below 10 GB are received and fully integrated with existing program data.
If a request is received to remove a person and their transactional data from a program, Evidence Engine has the ability to perform data removal to the exact standard defined by the request, including removal of data from original source files in the archive.
All files are retained in the Evidence Engine Azure data lake in their original format and kept for as long as needed.
All entities and transactions are assigned the unique master token ID to ensure linkage capabilities across programs as well as real world data.
Archive files are stored in a manner so if reprocessing of data is required it can be performed in the exact same order as the original order.
Data process and structures designed to provide full traceability and history retention on every data point in the warehouse.
Designed comprehensive and flexible models that meet the needs of specific areas. Models are based on standard industry models.
Standard models are configured and extended to meet the specific needs of a program to ensure the data collected and provided aligns with the defined parameters of the program.
On top of providing a standard model to define data points, measurement scales, and data formats, The Evidence Engine also implements a set of standard policies to define and control data access and usage standards.
Eliminate burden on the provider to meet model standards by receiving data in any format and field size instead of making the suppliers meet our standards. The Evidence Engine handles the mapping and transforms to align data with the program’s models.
The Evidence Engine contains an intelligent workflow automation engine that integrates with UBC core systems and offers a standard interface to exchange information with partners.
The Evidence Engine contains process engines that actively evaluate data to proactively locate errors in data and align the data to defined master standards.
When cleaning or master data conditions arise, The Evidence Engine will automatically correct and send notice of the correction when possible or will engage the event engine to initiate a notice or engage a workflow if human interaction is required.
By default, The Evidence Engine has standard cleaning and master data rules that can be used out of the box for a program, but these rules can be customized to meet a program's specific requirements.
Event processing can actively monitor for specific data occurrences or event triggers. Once activated, the event processing can engage a new workflow, pull additional data, build a data set, and fire a notification, to name a few examples.
Business Cases
Find Patients Faster
REDUCE SITE BURDEN
Patient Enrichment
Synergy Through alignment
Efficent Deployment
Analytics / AI
REDUCE SITE BURDEN THROUGH INTEROPERABILITY AND E-SOURCE
Access to Real World Data (RWD) markets allows programs to purchase targeted prospective and retrospective data for the patients in the program. This eliminates the burden of sites having to produce and enter the program applications while saving money through buying only the data for the patients involved in the program.
UBC’s Evidence Engine’s interoperability with health information exchanges and Electronic Health Records (EHR) systems enable programs to directly interface with a patient's records to pull data as it is entered and push request for actions (such as vital collections or lab requests) directly to the appropriate medical professional. Eliminating the entry of patient data into multiple systems greatly reduce the burden placed on site coordinators.
Patient Enrichment and Insights
The ability to link patients to real world data (RWD) expands the insights a program is able to gain about the patients without investing human hours to manually collect the data.
Example of a registry enhanced with RWD:
Subject count: 2,545
Subjects with entries in the marketplace: 2,445
Test of pharmacy and medical claims for the last two years, based on 2,445 subjects, produced 3.7 million medical claims transactions and 69,000 pharmacy transactions.
Synergy Through Alignment of Multiple Product Offerings
The Evidence Engine provides the ability to link patients across products and programs. This linkage streamlines operations, saves in human capital, and improves the services provided to the client.
More efficient SolutionS for Data Collection and Validation
Direct collection of data from Real World Data (RWD) markets and health networks saves money by reducing the human time required to perform duplicate data entry.
Patient linkage allows the same data point to be pulled from multiple sources to compare results. It allows for automated validation through system dual source verification. The auto validation process saves on the hours CRAs and sites have to spend verifying data as well as the travel costs required to support the verification process.
With automated data evaluation and verification, through system processes, the Evidence Engine can easily find common data entry errors and flag key events to automatically initiate workflows for sites and program team members. This reduces the data management costs of a program.
Find Patients faster
UBC utilizes scientific knowledge to build advanced query models against our Real-World Data (RWD) marketplace sources to build a population of potential patients that aligns with the patient model defined in the protocol.
If a company utilizes UBC for previous or current programs, the patients in these programs can formulate a base for other programs through the Evidence Engine’s function process to assign a single master token ID for all patients across all programs.
The Evidence Engine’s direct integration with Health Networks can directly query an Electronic Health Record (EHR) for a potential subject that meets the defined patient model for a program.
With this information, programs can perform targeted engagements with sites while still retaining the privacy of the patient.
Analytics / AI
UBC’s Evidence Engine is closely integrated with UBC's Analytics platform to provide a robust, advanced analytics and reporting platform.
The Evidence Engine’s Natural Language Processing (NLP) module programs can gain real world, detailed analysis through any form of free text sources, such as phone calls, emails, and patient
notes.
One component of automated processing in the Evidence Engine is machine learning. Using machine learning, the Evidence Engine can evaluate all data about a program (whether it is structured or unstructured) to find data correlations and insights that are not able to be caught by the human eye. As data increases, the Evidence Engine gains knowledge on the subject matter.
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